LipidDB ID

LipidDB-9606-00569

Entry Name

UniProt Accession

P16070; A5YRN9; B6EAT9; D3DR12; D3DR13; O95370; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; Q13960; Q13961; Q13967; Q13968; Q13980; Q15861; Q16064; Q16065; Q16066; Q16208; Q16522; Q86T72; Q86Z27; Q8N694; Q92493; Q96J24; Q9H5A5; Q9UC28; Q9UC29; Q9UC30; Q9UCB0; Q9UJ36;

Theoretical PI

5.13

Molecular Weight

81537.62

Genbank Protein ID

AAA35674.1; AAA51950.1; CAA38951.1; CAA40133.1; CAA47271.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13622.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13623.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13624.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13625.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13626.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13627.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; AAB13628.1; CAB61878.1; AAB27917.1; AAB27918.2; AAB27919.1; AAC70782.1; AAA82949.1; AAM50040.1; AAM50041.1; ABQ59315.1; ACI46596.1; CAD89965.1; CAC10347.1; EAW68147.1; EAW68148.1; EAW68149.1; EAW68151.1; EAW68152.1; AAH04372.1; AAH67348.1; AAA36138.1; CAA39404.1; AAB30429.1; CAA44602.1;

Genbank Nucleotide ID

M24915; M59040; X55150; X56794; X66733; L05423; L05407; L05408; L05409; L05410; L05420; L05421; L05422; M69215; L05423; L05407; L05408; L05410; L05411; L05412; L05414; L05415; L05416; L05417; L05418; L05419; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05411; L05412; L05414; L05416; L05417; L05418; L05419; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05411; L05412; L05414; L05416; L05417; L05418; L05419; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05417; L05418; L05420; L05421; L05422; M69215; L05424; L05407; L05408; L05410; L05411; L05412; L05414; L05415; L05416; L05417; L05418; L05419; L05420; L05421; L05422; M69215; AJ251595; S66400; S66400; S66400; AF098641; U40373; AY101192; AY101193; EF581837; FJ216964; AL832642; AL133330; AL136989; AL356215; CH471064; CH471064; CH471064; CH471064; CH471064; BC004372; BC067348; M25078; X55938; S72928; X62739;

Protein Name

CD44 antigen

Protein Synonyms/Alias

CDw44; Epican; Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD44;

Gene Name

CD44

Gene Synonyms/Alias

LHR; MDU2; MDU3; MIC4;

Created Date

01-APR-1990

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Thankamony SP, Knudson W. Acylation of CD44 and its association with lipidrafts are required for receptor and hyaluronan endocytosis. J Biol Chem. 2006 Nov10;281(45):34601-9. Epub 2006 Aug 30.[PMID:16945930]

Functional Description

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Sequence Annotation

Topological domain: 21 649 Extracellular.
Transmembrane: 650 670 Helical.
Topological domain: 671 742 Cytoplasmic.
Domain: 32 120 Link.
Region: 224 649 Stem.
Binding site: 41 41 Hyaluronan.
Binding site: 78 78 Hyaluronan.
Binding site: 79 79 Hyaluronan.
Binding site: 105 105 Hyaluronan.
Modified residue: 21 21 Pyrrolidone carboxylic acid.
Modified residue: 672 672 Phosphoserine; by PKC.
Modified residue: 686 686 Phosphoserine.
Modified residue: 697 697 Phosphoserine.
Modified residue: 706 706 Phosphoserine.

Protein Length

742 AA.

Protein Sequence
(Isoform 12)

FASTA
(Isoform 12)

Gene Ontology

GO:0016323; C:basolateral plasma membrane; IEA:Ensembl
GO:0009986; C:cell surface; IDA:UniProtKB
GO:0005737; C:cytoplasm; IDA:HPA
GO:0009897; C:external side of plasma membrane; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IDA:HPA
GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB
GO:0005886; C:plasma membrane; IDA:HPA
GO:0005518; F:collagen binding; NAS:UniProtKB
GO:0005540; F:hyaluronic acid binding; IDA:UniProtKB
GO:0004415; F:hyalurononglucosaminidase activity; IDA:UniProtKB
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0060442; P:branching involved in prostate gland morphogenesis; IEA:Ensembl
GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl
GO:0005975; P:carbohydrate metabolic process; TAS:Reactome
GO:0051216; P:cartilage development; IEP:UniProtKB
GO:0007160; P:cell-matrix adhesion; NAS:UniProtKB
GO:0044344; P:cellular response to fibroblast growth factor stimulus; IDA:UniProtKB
GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome
GO:0022617; P:extracellular matrix disassembly; TAS:Reactome
GO:0030198; P:extracellular matrix organization; TAS:Reactome
GO:0030203; P:glycosaminoglycan metabolic process; TAS:Reactome
GO:0030214; P:hyaluronan catabolic process; IDA:UniProtKB
GO:0030212; P:hyaluronan metabolic process; TAS:Reactome
GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome
GO:0050900; P:leukocyte migration; TAS:Reactome
GO:0070487; P:monocyte aggregation; IMP:UniProtKB
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB
GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB
GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IDA:BHF-UCL
GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IDA:BHF-UCL
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl
GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IMP:UniProtKB
GO:1900625; P:positive regulation of monocyte aggregation; IMP:BHF-UCL
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL
GO:0016337; P:single organismal cell-cell adhesion; NAS:UniProtKB
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0016055; P:Wnt signaling pathway; IEA:Ensembl
GO:0002246; P:wound healing involved in inflammatory response; IEA:Ensembl

Interpro

InterPro; IPR016186; C-type_lectin-like
InterPro; IPR016187; C-type_lectin_fold
InterPro; IPR001231; CD44_antigen
InterPro; IPR000538; Link

Pfam

Pfam; PF00193; Xlink;

SMART

SMART; SM00445; LINK;

PROSITE

PROSITE; PS01241; LINK_1;
PROSITE; PS50963; LINK_2;

PRINTS

PRINTS; PR00658; CD44;
PRINTS; PR01265; LINKMODULE;