LipidDB ID

LipidDB-9606-00556

Entry Name

UniProt Accession

P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2;

Theoretical PI

6.54

Molecular Weight

31462.79

Genbank Protein ID

AAA52408.1; AAC99788.1; AAP35708.1; CAI12225.1; CAI12226.1; CAI12228.1; AAH01169.1; AAC06298.1;

Genbank Nucleotide ID

M13450; AF112219; BT007059; AL136958; AL136958; AL136958; BC001169; AF052509;

Protein Name

S-formylglutathione hydrolase

Protein Synonyms/Alias

FGH; 3.1.2.12; Esterase D; Methylumbelliferyl-acetate deacetylase; 3.1.1.56;

Gene Name

ESD

Gene Synonyms/Alias

Created Date

01-JUL-1989

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Serine hydrolase involved in the detoxification of formaldehyde.

Sequence Annotation

Active site: 149 149 Charge relay system.
Active site: 226 226 Charge relay system.
Active site: 260 260 Charge relay system.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 4 4 N6-succinyllysine.
Modified residue: 200 200 N6-acetyllysine.

Protein Length

282 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:HPA
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IDA:HPA
GO:0005634; C:nucleus; IDA:HPA
GO:0005886; C:plasma membrane; IDA:HPA
GO:0052689; F:carboxylic ester hydrolase activity; NAS:UniProtKB
GO:0016788; F:hydrolase activity, acting on ester bonds; IDA:UniProt
GO:0047374; F:methylumbelliferyl-acetate deacetylase activity; IEA:UniProtKB-EC
GO:0018738; F:S-formylglutathione hydrolase activity; IEA:UniProtKB-EC
GO:0046294; P:formaldehyde catabolic process; IEA:InterPro

Interpro

InterPro; IPR029058; AB_hydrolase
InterPro; IPR000801; Esterase_put
InterPro; IPR014186; S-formylglutathione_hydrol

Pfam

Pfam; PF00756; Esterase;

SMART

PROSITE

PRINTS