Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00544
Entry Name
UniProt Accession
Theoretical PI
4.94
Molecular Weight
42075.95
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Paralemmin-1
Protein Synonyms/Alias
Paralemmin;
Gene Name
PALM
Gene Synonyms/Alias
KIAA0270;
Created Date
30-AUG-2002
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
383
Canonical
MKKHRCKCCSIM***
[1]
S-Palmitoylation
384
Canonical
KKHRCKCCSIM****
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.
Sequence Annotation
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 116 116 Phosphoserine.
Modified residue: 124 124 Phosphoserine.
Modified residue: 141 141 Phosphothreonine.
Modified residue: 145 145 Phosphothreonine.
Modified residue: 162 162 Phosphoserine.
Modified residue: 346 346 Phosphoserine.
Modified residue: 384 384 Cysteine methyl ester.
Protein Length
387 AA.
Protein Sequence
(Canonical)
MEVLAAETTS QQERLQAIAE KRKRQAEIEN KRRQLEDERR QLQHLKSKAL RERWLLEGTP  60
SSASEGDEDL RRQMQDDEQK TRLLEDSVSR LEKEIEVLER GDSAPATAKE NAAAPSPVRA  120
PAPSPAKEER KTEVVMNSQQ TPVGTPKDKR VSNTPLRTVD GSPMMKAAMY SVEITVEKDK  180
VTGETRVLSS TTLLPRQPLP LGIKVYEDET KVVHAVDGTA ENGIHPLSSS EVDELIHKAD  240
EVTLSEAGST AGAAETRGAV EGAARTTPSR REITGVQAQP GEATSGPPGI QPGQEPPVTM  300
IFMGYQNVED EAETKKVLGL QDTITAELVV IEDAAEPKEP APPNGSAAEP PTEAASREEN  360
QAGPEATTSD PQDLDMKKHR CKCCSIM                                      387
FASTA
(Canonical)
>LipidDB-9606-00544|O75781
MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTP
SSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRA
PAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGSPMMKAAMYSVEITVEKDK
VTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKAD
EVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTM
IFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEPPTEAASREEN
QAGPEATTSDPQDLDMKKHRCKCCSIM
Gene Ontology
GO:0016327; C:apicolateral plasma membrane; IEA:Ensembl
GO:0030424; C:axon; IEA:Ensembl
GO:0016323; C:basolateral plasma membrane; IEA:Ensembl
GO:0016023; C:cytoplasmic membrane-bounded vesicle; TAS:ProtInc
GO:0032590; C:dendrite membrane; IEA:Ensembl
GO:0032591; C:dendritic spine membrane; IEA:Ensembl
GO:0031527; C:filopodium membrane; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0005634; C:nucleus; IDA:HPA
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0006928; P:cellular component movement; TAS:ProtInc
GO:0071257; P:cellular response to electrical stimulus; IEA:Ensembl
GO:0007010; P:cytoskeleton organization; IEA:Ensembl
GO:0007194; P:negative regulation of adenylate cyclase activity; IDA:UniProtKB
GO:0060160; P:negative regulation of dopamine receptor signaling pathway; IDA:UniProtKB
GO:0060999; P:positive regulation of dendritic spine development; IEA:Ensembl
GO:0051491; P:positive regulation of filopodium assembly; IDA:UniProtKB
GO:0072661; P:protein targeting to plasma membrane; IEA:Ensembl
GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW
GO:0060074; P:synapse maturation; IEA:Ensembl
Interpro
InterPro; IPR004965; Paralemmin
Pfam
Pfam; PF03285; Paralemmin;
SMART
PROSITE
PRINTS