LipidDB ID

LipidDB-9606-00539

Entry Name

UniProt Accession

P09769; D3DPL7; Q9UIQ3;

Theoretical PI

5.41

Molecular Weight

59478.62

Genbank Protein ID

AAA52451.1; CAB62998.1; EAX07748.1; EAX07749.1; EAX07750.1; AAH64382.1; CAA36457.2; CAA36457.2; AAA52762.1; AAA52762.1; AAA52762.1; AAA52762.1; AAA52762.1; AAA52762.1;

Genbank Nucleotide ID

M19722; AL031729; CH471059; CH471059; CH471059; BC064382; X52207; X52208; M12724; M12719; M12720; M12721; M12722; M12723;

Protein Name

Tyrosine-protein kinase Fgr

Protein Synonyms/Alias

2.7.10.2; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; Proto-oncogene c-Fgr; p55-Fgr; p58-Fgr; p58c-Fgr;

Gene Name

FGR

Gene Synonyms/Alias

SRC2;

Created Date

01-JUL-1989

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Baker SJ, Cosenza SC, Reddy EP. The role of v-Fgr myristoylation and the Gagdomain in membrane binding and cellular transformation. Virology. 1998 Sep15;249(1):1-11.[PMID:9740771]

Functional Description

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK- dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.

Sequence Annotation

Domain: 77 138 SH3.
Domain: 144 241 SH2.
Domain: 263 516 Protein kinase.
Nucleotide-binding: 269 277 ATP.
Active site: 382 382 Proton acceptor.
Binding site: 291 291 ATP.
Modified residue: 34 34 Phosphotyrosine.
Modified residue: 412 412 Phosphotyrosine.
Modified residue: 523 523 Phosphotyrosine; by SRC.

Protein Length

529 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0015629; C:actin cytoskeleton; IEA:Ensembl
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; ISS:UniProtKB
GO:0032587; C:ruffle membrane; IEA:Ensembl
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0034988; F:Fc-gamma receptor I complex binding; IDA:UniProtKB
GO:0034987; F:immunoglobulin receptor binding; ISS:UniProtKB
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB
GO:0001784; F:phosphotyrosine binding; ISS:UniProtKB
GO:0019901; F:protein kinase binding; ISS:UniProtKB
GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome
GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; TAS:UniProtKB
GO:0045087; P:innate immune response; TAS:Reactome
GO:0007229; P:integrin-mediated signaling pathway; IMP:UniProtKB
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB
GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB
GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB
GO:0043306; P:positive regulation of mast cell degranulation; ISS:UniProtKB
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:UniProtKB
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IMP:UniProtKB
GO:0046777; P:protein autophosphorylation; IDA:UniProtKB
GO:0006468; P:protein phosphorylation; TAS:ProtInc
GO:0008360; P:regulation of cell shape; ISS:UniProtKB
GO:0045088; P:regulation of innate immune response; ISS:UniProtKB
GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB
GO:0045859; P:regulation of protein kinase activity; ISS:UniProtKB
GO:0009615; P:response to virus; TAS:ProtInc

Interpro

InterPro; IPR028459; FGR
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom
InterPro; IPR000980; SH2
InterPro; IPR001452; SH3_domain
InterPro; IPR008266; Tyr_kinase_AS
InterPro; IPR020635; Tyr_kinase_cat_dom

Pfam

Pfam; PF07714; Pkinase_Tyr;
Pfam; PF00017; SH2;
Pfam; PF00018; SH3_1;

SMART

SMART; SM00252; SH2;
SMART; SM00326; SH3;
SMART; SM00219; TyrKc;

PROSITE

PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;
PROSITE; PS00109; PROTEIN_KINASE_TYR;
PROSITE; PS50001; SH2;
PROSITE; PS50002; SH3;

PRINTS

PRINTS; PR00401; SH2DOMAIN;
PRINTS; PR00452; SH3DOMAIN;
PRINTS; PR00109; TYRKINASE;