Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00525
Entry Name
UniProt Accession
Theoretical PI
5.2
Molecular Weight
38808.07
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Nuclear distribution protein nudE homolog 1
Protein Synonyms/Alias
NudE;
Gene Name
NDE1
Gene Synonyms/Alias
NUDE;
Created Date
13-JUN-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
274
Canonical
LESKLASCRNLVYDQ
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Shmueli A, Segal M, Sapir T, Tsutsumi R, Noritake J, Bar A, Sapoznik S, FukataY, Orr I, Fukata M, Reiner O. Ndel1 palmitoylation: a new mean to regulatecytoplasmic dynein activity. EMBO J. 2010 Jan 6;29(1):107-19. doi:10.1038/emboj.2009.325. Epub 2009 Nov 19.[PMID:19927128]
Functional Description
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
Sequence Annotation
Region: 1 93 Self-association.
Region: 88 156 Interaction with PAFAH1B1.
Region: 167 290 Interaction with CENPF.
Modified residue: 211 211 Phosphoserine.
Modified residue: 215 215 Phosphothreonine.
Modified residue: 228 228 Phosphothreonine.
Modified residue: 231 231 Phosphoserine.
Modified residue: 239 239 Phosphoserine.
Modified residue: 243 243 Phosphothreonine.
Modified residue: 246 246 Phosphothreonine.
Modified residue: 282 282 Phosphoserine.
Protein Length
346 AA.
Protein Sequence
(Canonical)
MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL ETQLQQIETR  60
NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA  120
NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL  180
AVQQKQEKPR TPMPSSVEAE RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST  240
GGTPLTPAAR ISALNIVGDL LRKVGALESK LASCRNLVYD QSPNRTGGPA SGRSSKNRDG  300
GERRPSSTSV PLGDKGLGKR LEFGKPPSHM SSSPLPSAQG VVKMLL                 346
FASTA
(Canonical)
>LipidDB-9606-00525|Q9NXR1
MEDSGKTFSSEEEEANYWKDLAMTYKQRAENTQEELREFQEGSREYEAELETQLQQIETR
NRDLLSENNRLRMELETIKEKFEVQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQA
NDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQEL
AVQQKQEKPRTPMPSSVEAERTDTAVQATGSVPSTPIAHRGPSSSLNTPGSFRRGLDDST
GGTPLTPAARISALNIVGDLLRKVGALESKLASCRNLVYDQSPNRTGGPASGRSSKNRDG
GERRPSSTSVPLGDKGLGKRLEFGKPPSHMSSSPLPSAQGVVKMLL
Gene Ontology
GO:0005813; C:centrosome; IDA:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0000776; C:kinetochore; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005874; C:microtubule; IEA:UniProtKB-KW
GO:0031616; C:spindle pole centrosome; ISS:UniProtKB
GO:0008017; F:microtubule binding; ISS:UniProtKB
GO:0051298; P:centrosome duplication; ISS:UniProtKB
GO:0021987; P:cerebral cortex development; IMP:UniProtKB
GO:0051303; P:establishment of chromosome localization; IMP:UniProtKB
GO:0000132; P:establishment of mitotic spindle orientation; IMP:UniProtKB
GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome
GO:0007020; P:microtubule nucleation; IEA:Ensembl
GO:0000278; P:mitotic cell cycle; TAS:Reactome
GO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW
GO:0007405; P:neuroblast proliferation; IEA:Ensembl
GO:0001764; P:neuron migration; IEA:Ensembl
GO:0047496; P:vesicle transport along microtubule; IEA:Ensembl
Interpro
InterPro; IPR006964; NUDE_C
Pfam
Pfam; PF04880; NUDE_C;
SMART
PROSITE
PRINTS