LipidDB ID

LipidDB-9606-00522

Entry Name

UniProt Accession

P11233; A4D1W3;

Theoretical PI

6.66

Molecular Weight

23566.79

Genbank Protein ID

CAA33118.1; AAA36542.1; AAM12624.1; EAL23994.1; EAW94123.1; AAH39858.1;

Genbank Nucleotide ID

X15014; M29893; AF493910; AC004837; CH236951; CH471073; BC039858;

Protein Name

Ras-related protein Ral-A

Protein Synonyms/Alias

Gene Name

RALA

Gene Synonyms/Alias

RAL;

Created Date

01-JUL-1989

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid
[2] Kinsella BT, Erdman RA, Maltese WA. Carboxyl-terminal isoprenylation ofras-related GTP-binding proteins encoded by rac1, rac2, and ralA. J Biol Chem.1991 May 25;266(15):9786-94.[PMID:1903399]
[3] Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, SebtiSM. Geranylgeranyltransferase I inhibitors target RalB to inhibitanchorage-dependent growth and induce apoptosis and RalA to inhibitanchorage-independent growth. Mol Cell Biol. 2007 Nov;27(22):8003-14. Epub 2007Sep 17.[PMID:17875936]

Functional Description

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

Sequence Annotation

Nucleotide-binding: 24 29 GTP.
Nucleotide-binding: 40 46 GTP.
Nucleotide-binding: 127 130 GTP.
Motif: 43 51 Effector region.
Modified residue: 203 203 Cysteine methyl ester.

Protein Length

206 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009986; C:cell surface; IDA:UniProtKB
GO:0032154; C:cleavage furrow; IDA:UniProtKB
GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0031755; F:Edg-2 lysophosphatidic acid receptor binding; IDA:UniProtKB
GO:0005525; F:GTP binding; TAS:ProtInc
GO:0003924; F:GTPase activity; IEA:InterPro
GO:0031532; P:actin cytoskeleton reorganization; IDA:BHF-UCL
GO:0006935; P:chemotaxis; TAS:ProtInc
GO:0000910; P:cytokinesis; IDA:UniProtKB
GO:0006887; P:exocytosis; IEA:UniProtKB-KW
GO:0061024; P:membrane organization; TAS:Reactome
GO:0051665; P:membrane raft localization; IDA:UniProtKB
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome
GO:0051491; P:positive regulation of filopodium assembly; IDA:BHF-UCL
GO:0007265; P:Ras protein signal transduction; TAS:Reactome
GO:0017157; P:regulation of exocytosis; IDA:UniProtKB
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0016032; P:viral process; IEA:UniProtKB-KW

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR028412; Ral
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;