LipidDB ID

LipidDB-9606-00510

Entry Name

UniProt Accession

P24530; A2A2Z8; A8K3T4; O15343; Q59GB1; Q5W0G9; Q8NHM6; Q8NHM7; Q8NHM8; Q8NHM9; Q9UD23; Q9UQK3;

Theoretical PI

9.15

Molecular Weight

49643.87

Genbank Protein ID

AAA58465.1; BAA14398.1; AAB19411.1; AAB25531.1; BAA02445.1; AAA52342.1; CAA67623.1; AAD24541.1; AAP32295.1; BAD92435.1; BAF83388.1; AAS38516.1; CAM16893.1; CAH72430.1; EAW80573.1; EAW80575.1; AAH14472.1; CAD30645.1; CAD30646.1; CAD30647.1; CAD30648.1;

Genbank Nucleotide ID

M74921; D90402; S44866; S57283; D13168; L06623; X99250; AF114165; AY275463; AB209198; AK290699; AY547312; AL139002; AL139002; CH471093; CH471093; BC014472; AJ458188; AJ458189; AJ458190; AJ458191;

Protein Name

Endothelin B receptor

Protein Synonyms/Alias

ET-B; ET-BR; Endothelin receptor non-selective type;

Gene Name

EDNRB

Gene Synonyms/Alias

ETRB;

Created Date

01-MAR-1992

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Stannard C, Lehenkari P, Godovac-Zimmermann J. Functional diversity ofendothelin pathways in human lung fibroblasts may be based on structuraldiversity of the endothelin receptors. Biochemistry. 2003 Dec 2;42(47):13909-18.[PMID:14636059]
[2] Okamoto Y, Ninomiya H, Masaki T. Posttranslational modifications of endothelinreceptor type B. Trends Cardiovasc Med. 1998 Nov;8(8):327-9.[PMID:14987546]

Functional Description

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Sequence Annotation

Topological domain: 27 101 Extracellular.
Transmembrane: 102 126 Helical; Name=1.
Topological domain: 127 137 Cytoplasmic.
Transmembrane: 138 163 Helical; Name=2.
Topological domain: 164 175 Extracellular.
Transmembrane: 176 197 Helical; Name=3.
Topological domain: 198 218 Cytoplasmic.
Transmembrane: 219 243 Helical; Name=4.
Topological domain: 244 271 Extracellular.
Transmembrane: 272 296 Helical; Name=5.
Topological domain: 297 324 Cytoplasmic.
Transmembrane: 325 350 Helical; Name=6.
Topological domain: 351 362 Extracellular.
Transmembrane: 363 389 Helical; Name=7.
Topological domain: 390 442 Cytoplasmic.
Modified residue: 305 305 Phosphoserine.
Modified residue: 419 419 Phosphoserine.
Modified residue: 439 439 Phosphotyrosine.
Modified residue: 440 440 Phosphoserine.
Modified residue: 441 441 Phosphoserine.
Modified residue: 442 442 Phosphoserine.

Protein Length

442 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0031965; C:nuclear membrane; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0004962; F:endothelin receptor activity; IDA:BHF-UCL
GO:0017046; F:peptide hormone binding; IPI:BHF-UCL
GO:0007568; P:aging; IEA:Ensembl
GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc
GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl
GO:0019934; P:cGMP-mediated signaling; IEA:Ensembl
GO:0086100; P:endothelin receptor signaling pathway; IDA:GOC
GO:0048484; P:enteric nervous system development; ISS:BHF-UCL
GO:0035645; P:enteric smooth muscle cell differentiation; ISS:BHF-UCL
GO:0042045; P:epithelial fluid transport; IEA:Ensembl
GO:0048246; P:macrophage chemotaxis; IMP:BHF-UCL
GO:0030318; P:melanocyte differentiation; IEA:Ensembl
GO:0007194; P:negative regulation of adenylate cyclase activity; TAS:ProtInc
GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl
GO:0032269; P:negative regulation of cellular protein metabolic process; IMP:BHF-UCL
GO:0014043; P:negative regulation of neuron maturation; ISS:BHF-UCL
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL
GO:0007399; P:nervous system development; TAS:ProtInc
GO:0001755; P:neural crest cell migration; IEA:Ensembl
GO:0007422; P:peripheral nervous system development; IEA:Ensembl
GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; TAS:ProtInc
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl
GO:0060406; P:positive regulation of penile erection; IEA:Ensembl
GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl
GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl
GO:0035810; P:positive regulation of urine volume; IEA:Ensembl
GO:0007497; P:posterior midgut development; IEA:Ensembl
GO:0008217; P:regulation of blood pressure; IEA:Ensembl
GO:0050678; P:regulation of epithelial cell proliferation; IEA:Ensembl
GO:0031620; P:regulation of fever generation; IEA:Ensembl
GO:0006885; P:regulation of pH; IEA:Ensembl
GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl
GO:0048265; P:response to pain; IEA:Ensembl
GO:0019233; P:sensory perception of pain; IEA:Ensembl
GO:0042310; P:vasoconstriction; IMP:BHF-UCL
GO:0042311; P:vasodilation; IEA:Ensembl
GO:0014826; P:vein smooth muscle contraction; IMP:BHF-UCL

Interpro

InterPro; IPR000499; Endthln_rcpt
InterPro; IPR001112; ETB_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00571; ENDOTHELINBR;
PRINTS; PR00366; ENDOTHELINR;
PRINTS; PR00237; GPCRRHODOPSN;