LipidDB ID

LipidDB-9606-00507

Entry Name

UniProt Accession

Q99828; B5BU40; H6WJF3; O00693; O00735; Q6IB49; Q96J54; Q99971;

Theoretical PI

4.65

Molecular Weight

21703.39

Genbank Protein ID

AAC51106.1; AAB53387.1; BAA36281.1; AEZ06077.1; AAB39758.1; CAG33236.1; BAG70090.1; BAG70220.1; EAX02090.1; AAH00846.1;

Genbank Nucleotide ID

U82226; U85611; AB021866; JQ246073; U83236; CR456955; AB451276; AB451406; CH471101; BC000846;

Protein Name

Calcium and integrin-binding protein 1

Protein Synonyms/Alias

CIB; Calcium- and integrin-binding protein; CIBP; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; SNK-interacting protein 2-28; SIP2-28;

Gene Name

CIB1

Gene Synonyms/Alias

CIB; KIP; PRKDCIP;

Created Date

01-NOV-1997

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Stabler SM, Ostrowski LL, Janicki SM, Monteiro MJ. A myristoylatedcalcium-binding protein that preferentially interacts with the Alzheimer'sdisease presenilin 2 protein. J Cell Biol. 1999 Jun 14;145(6):1277-92. PubMedPMID: 10366599; PubMed Central PMCID: PMC2133148.[PMID:10366599]

Functional Description

Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin- stimulated megakaryocytes preventing platelet aggregation. Up- regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N- myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

Sequence Annotation

Domain: 103 138 EF-hand 1.
Domain: 148 183 EF-hand 2.
Modified residue: 78 78 Phosphoserine; by PKD/PRKD2; in isoform2.

Protein Length

191 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0071944; C:cell periphery; IDA:UniProtKB
GO:0005813; C:centrosome; IDA:UniProtKB
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005783; C:endoplasmic reticulum; IMP:HGNC
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0032433; C:filopodium tip; IDA:UniProtKB
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0030426; C:growth cone; IDA:UniProtKB
GO:0030027; C:lamellipodium; IDA:UniProtKB
GO:0016020; C:membrane; IDA:HGNC
GO:0043005; C:neuron projection; IDA:UniProtKB
GO:0043025; C:neuronal cell body; IDA:UniProtKB
GO:0005654; C:nucleoplasm; IMP:HGNC
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0042383; C:sarcolemma; IDA:BHF-UCL
GO:0031982; C:vesicle; IDA:UniProtKB
GO:0005509; F:calcium ion binding; IMP:HGNC
GO:0043495; F:protein anchor; IGI:BHF-UCL
GO:0017016; F:Ras GTPase binding; IPI:UniProtKB
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW
GO:0006915; P:apoptotic process; IMP:HGNC
GO:0007155; P:cell adhesion; TAS:ProtInc
GO:0051301; P:cell division; IEA:UniProtKB-KW
GO:0006974; P:cellular response to DNA damage stimulus; IDA:HGNC
GO:0071363; P:cellular response to growth factor stimulus; ISS:UniProtKB
GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:UniProtKB
GO:0071356; P:cellular response to tumor necrosis factor; IMP:UniProtKB
GO:0031122; P:cytoplasmic microtubule organization; IMP:UniProtKB
GO:0006302; P:double-strand break repair; TAS:ProtInc
GO:0007113; P:endomitotic cell cycle; IDA:UniProtKB
GO:0097191; P:extrinsic apoptotic signaling pathway; TAS:BHF-UCL
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB
GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB
GO:0045653; P:negative regulation of megakaryocyte differentiation; ISS:UniProtKB
GO:0007026; P:negative regulation of microtubule depolymerization; IDA:UniProtKB
GO:0010977; P:negative regulation of neuron projection development; IDA:UniProtKB
GO:0051898; P:negative regulation of protein kinase B signaling; ISS:UniProtKB
GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB
GO:0030220; P:platelet formation; ISS:UniProtKB
GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IDA:BHF-UCL
GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IDA:UniProtKB
GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB
GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB
GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:UniProtKB
GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB
GO:0001954; P:positive regulation of cell-matrix adhesion; ISS:UniProtKB
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IGI:BHF-UCL
GO:1901313; P:positive regulation of gene expression involved in extracellular matrix organization; ISS:UniProtKB
GO:2000256; P:positive regulation of male germ cell proliferation; ISS:UniProtKB
GO:0048554; P:positive regulation of metalloenzyme activity; ISS:UniProtKB
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB
GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB
GO:0071902; P:positive regulation of protein serine/threonine kinase activity; ISS:UniProtKB
GO:0090314; P:positive regulation of protein targeting to membrane; IMP:UniProtKB
GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IDA:UniProtKB
GO:0051302; P:regulation of cell division; IMP:UniProtKB
GO:0042127; P:regulation of cell proliferation; IMP:UniProtKB
GO:0002931; P:response to ischemia; ISS:UniProtKB
GO:0007286; P:spermatid development; ISS:UniProtKB
GO:0038163; P:thrombopoietin-mediated signaling pathway; ISS:UniProtKB

Interpro

InterPro; IPR011992; EF-hand-dom_pair
InterPro; IPR018247; EF_Hand_1_Ca_BS
InterPro; IPR002048; EF_hand_dom

Pfam

Pfam; PF13499; EF-hand_7;

SMART

SMART; SM00054; EFh;

PROSITE

PROSITE; PS00018; EF_HAND_1;
PROSITE; PS50222; EF_HAND_2;

PRINTS