LipidDB ID

LipidDB-9606-00502

Entry Name

UniProt Accession

Q93045; A8K9M2; G3V110; O14952; Q6PK68;

Theoretical PI

8.4

Molecular Weight

20828.05

Genbank Protein ID

AAB36428.1; BAA23326.1; AAV38837.1; CAG33114.1; BAF85426.1; EAW87064.1; EAW87065.1; AAH06302.1;

Genbank Nucleotide ID

S82024; D50375; BT020034; CR456833; AK292737; AC016240; AC025599; CH471068; CH471068; BC006302; BQ069488;

Protein Name

Stathmin-2

Protein Synonyms/Alias

Superior cervical ganglion-10 protein; Protein SCG10;

Gene Name

STMN2

Gene Synonyms/Alias

SCG10; SCGN10;

Created Date

01-NOV-1997

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Di Paolo G, Lutjens R, Pellier V, Stimpson SA, Beuchat MH, Catsicas S,Grenningloh G. Targeting of SCG10 to the area of the Golgi complex is mediated byits NH2-terminal region. J Biol Chem. 1997 Feb 21;272(8):5175-82.[PMID:9030585]

Functional Description

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity).

Sequence Annotation

Domain: 38 179 SLD.
Region: 1 26 Membrane attachment.
Region: 39 96 Regulatory/phosphorylation domain.
Modified residue: 16 16 Phosphoserine.
Modified residue: 50 50 Phosphoserine.
Modified residue: 62 62 Phosphoserine.
Modified residue: 73 73 Phosphoserine.
Modified residue: 97 97 Phosphoserine.

Protein Length

179 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0030426; C:growth cone; IDA:UniProtKB
GO:0030027; C:lamellipodium; IDA:UniProtKB
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0043005; C:neuron projection; IDA:UniProtKB
GO:0043025; C:neuronal cell body; IDA:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB
GO:0031982; C:vesicle; IEA:Ensembl
GO:0048306; F:calcium-dependent protein binding; IPI:UniProtKB
GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:UniProtKB
GO:0007026; P:negative regulation of microtubule depolymerization; IDA:UniProtKB
GO:0031115; P:negative regulation of microtubule polymerization; IDA:UniProtKB
GO:0010977; P:negative regulation of neuron projection development; IDA:UniProtKB
GO:0031117; P:positive regulation of microtubule depolymerization; IDA:UniProtKB
GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB

Interpro

InterPro; IPR026729; Stathmin-2
InterPro; IPR000956; Stathmin_fam

Pfam

Pfam; PF00836; Stathmin;

SMART

PROSITE

PROSITE; PS00563; STATHMIN_1;
PROSITE; PS01041; STATHMIN_2;
PROSITE; PS51663; STATHMIN_3;

PRINTS

PRINTS; PR00345; STATHMIN;