LipidDB ID

LipidDB-9606-00498

Entry Name

UniProt Accession

Q9C0E8; B7ZLA8; Q2M2V8; Q2YD99; Q658W8; Q8N5V9; Q96MS5;

Theoretical PI

5.05

Molecular Weight

47739.92

Genbank Protein ID

BAB21806.1; BAB71207.1; AAH31530.1; AAI05133.1; AAI05135.1; AAI10330.1; AAI43682.1; CAH56306.1;

Genbank Nucleotide ID

AB051502; AK056532; AC016751; AC016915; BC031530; BC105132; BC105134; BC110329; BC143681; AL832947;

Protein Name

Protein lunapark

Protein Synonyms/Alias

Gene Name

LNP

Gene Synonyms/Alias

KIAA1715;

Created Date

05-SEP-2006

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Suzuki T, Moriya K, Nagatoshi K, Ota Y, Ezure T, Ando E, Tsunasawa S, UtsumiT. Strategy for comprehensive identification of human N-myristoylated proteinsusing an insect cell-free protein synthesis system. Proteomics. 2010May;10(9):1780-93. doi: 10.1002/pmic.200900783.[PMID:20213681]
[2] Moriya K, Nagatoshi K, Noriyasu Y, Okamura T, Takamitsu E, Suzuki T, Utsumi T.Protein N-myristoylation plays a critical role in the endoplasmic reticulummorphological change induced by overexpression of protein Lunapark, an integralmembrane protein of the endoplasmic reticulum. PLoS One. 2013 Nov 4;8(11):e78235.doi: 10.1371/journal.pone.0078235. eCollection 2013.[PMID:24223779]

Functional Description

Plays a role in tubular endoplasmic reticulum network formation and maintenance. May be involved in limb and central nervous system development.

Sequence Annotation

Topological domain: 2 45 Cytoplasmic.
Transmembrane: 46 66 Helical.
Topological domain: 67 77 Lumenal.
Transmembrane: 78 98 Helical.
Topological domain: 99 428 Cytoplasmic.
Modified residue: 177 177 Phosphoserine.
Modified residue: 182 182 Phosphoserine.
Modified residue: 194 194 Phosphoserine.
Modified residue: 321 321 Phosphoserine.
Modified residue: 414 414 Phosphoserine.

Protein Length

428 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI
GO:0016021; C:integral component of membrane; NAS:UniProtKB
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0007596; P:blood coagulation; IEA:Ensembl
GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl
GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl
GO:0060173; P:limb development; NAS:UniProtKB
GO:0032330; P:regulation of chondrocyte differentiation; IEA:Ensembl

Interpro

InterPro; IPR019273; DUF2296

Pfam

Pfam; PF10058; DUF2296;

SMART

PROSITE

PRINTS