Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00494
Entry Name
UniProt Accession
Theoretical PI
6.29
Molecular Weight
23948.66
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Calcium-activated potassium channel subunit beta-4
Protein Synonyms/Alias
BK channel subunit beta-4; BKbeta4; Hbeta4; Calcium-activated potassium channel, subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; K(VCA)beta-4; Maxi K channel subunit beta-4; Slo-beta-4;
Gene Name
KCNMB4
Gene Synonyms/Alias
Created Date
13-APR-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
193
Canonical
LIVVLTICAKSLAVK
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Chen L, Bi D, Tian L, McClafferty H, Steeb F, Ruth P, Knaus HG, Shipston MJ.Palmitoylation of the β4-subunit regulates surface expression of largeconductance calcium-activated potassium channel splice variants. J Biol Chem.2013 May 3;288(18):13136-44. doi: 10.1074/jbc.M113.461830. Epub 2013 Mar 16.[PMID:23504458]
Functional Description
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
Sequence Annotation
Topological domain: 1 19 Cytoplasmic.
Transmembrane: 20 40 Helical; Name=1.
Topological domain: 41 167 Extracellular.
Transmembrane: 168 188 Helical; Name=2.
Topological domain: 189 210 Cytoplasmic.
Protein Length
210 AA.
Protein Sequence
(Canonical)
MAKLRVAYEY TEAEDKSIRL GLFLIISGVV SLFIFGFCWL SPALQDLQAT EANCTVLSVQ  60
QIGEVFECTF TCGADCRGTS QYPCVQVYVN NSESNSRALL HSDEHQLLTN PKCSYIPPCK  120
RENQKNLESV MNWQQYWKDE IGSQPFTCYF NQHQRPDDVL LHRTHDEIVL LHCFLWPLVT  180
FVVGVLIVVL TICAKSLAVK AEAMKKRKFS                                   210
FASTA
(Canonical)
>LipidDB-9606-00494|Q86W47
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQ
QIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCK
RENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVT
FVVGVLIVVLTICAKSLAVKAEAMKKRKFS
Gene Ontology
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0008076; C:voltage-gated potassium channel complex; IDA:UniProtKB
GO:0015269; F:calcium-activated potassium channel activity; IDA:UniProtKB
GO:0001508; P:action potential; IDA:UniProtKB
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0005513; P:detection of calcium ion; IDA:UniProtKB
GO:0019228; P:neuronal action potential; IDA:UniProtKB
GO:0071805; P:potassium ion transmembrane transport; IDA:GOC
GO:0006813; P:potassium ion transport; IDA:UniProtKB
GO:0046928; P:regulation of neurotransmitter secretion; TAS:UniProtKB
GO:0019229; P:regulation of vasoconstriction; TAS:UniProtKB
GO:0007268; P:synaptic transmission; TAS:Reactome
Interpro
InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu
Pfam
Pfam; PF03185; CaKB;
SMART
PROSITE
PRINTS