Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00489
Entry Name
UniProt Accession
Theoretical PI
6.19
Molecular Weight
35000.68
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-a
Protein Synonyms/Alias
IgG Fc receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD32;
Gene Name
FCGR2A
Gene Synonyms/Alias
CD32; FCG2; FCGR2A1; IGFR2;
Created Date
01-OCT-1989
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
241
Canonical
AVVALIYCRKKRISA
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Barnes NC, Powell MS, Trist HM, Gavin AL, Wines BD, Hogarth PM. Raftlocalisation of FcgammaRIIa and efficient signaling are dependent onpalmitoylation of cysteine 208. Immunol Lett. 2006 Apr 15;104(1-2):118-23. Epub2005 Dec 5.[PMID:16375976]
Functional Description
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Sequence Annotation
Topological domain: 34 217 Extracellular.
Transmembrane: 218 240 Helical.
Topological domain: 241 317 Cytoplasmic.
Domain: 39 118 Ig-like C2-type 1.
Domain: 122 204 Ig-like C2-type 2.
Modified residue: 288 288 Phosphotyrosine; by SRC-type Tyr-kinases.
Modified residue: 304 304 Phosphotyrosine; by SRC-type Tyr-kinases.
Protein Length
317 AA.
Protein Sequence
(Canonical)
MTMETQMSQN VCPRNLWLLQ PLTVLLLLAS ADSQAAAPPK AVLKLEPPWI NVLQEDSVTL  60
TCQGARSPES DSIQWFHNGN LIPTHTQPSY RFKANNNDSG EYTCQTGQTS LSDPVHLTVL  120
SEWLVLQTPH LEFQEGETIM LRCHSWKDKP LVKVTFFQNG KSQKFSHLDP TFSIPQANHS  180
HSGDYHCTGN IGYTLFSSKP VTITVQVPSM GSSSPMGIIV AVVIATAVAA IVAAVVALIY  240
CRKKRISANS TDPVKAAQFE PPGRQMIAIR KRQLEETNND YETADGGYMT LNPRAPTDDD  300
KNIYLTLPPN DHVNSNN                                                 317
FASTA
(Canonical)
>LipidDB-9606-00489|P12318
MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTL
TCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVL
SEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNGKSQKFSHLDPTFSIPQANHS
HSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGIIVAVVIATAVAAIVAAVVALIY
CRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNNDYETADGGYMTLNPRAPTDDD
KNIYLTLPPNDHVNSNN
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome
GO:0045087; P:innate immune response; TAS:Reactome
Interpro
InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003599; Ig_sub
Pfam
SMART
SMART; SM00409; IG;
PROSITE
PROSITE; PS50835; IG_LIKE;
PRINTS