Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00488
Entry Name
UniProt Accession
Theoretical PI
8.55
Molecular Weight
39646.25
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Mitochondrial import inner membrane translocase subunit TIM50
Protein Synonyms/Alias
Gene Name
TIMM50
Gene Synonyms/Alias
TIM50; PRO1512;
Created Date
06-DEC-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
133
Canonical
IIEPTSPCLLPDPLQ
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.
Sequence Annotation
Topological domain: 45 65 Mitochondrial matrix.
Transmembrane: 66 86 Helical.
Topological domain: 87 353 Mitochondrial intermembrane.
Domain: 143 286 FCP1 homology.
Protein Length
353 AA.
Protein Sequence
(Canonical)
MAASAAVFSR LRSGLRLGSR GLCTRLATPP RRAPDQAAEI GSRGSTKAQG PQQQPGSEGP  60
SYAKKVALWL AGLLGAGGTV SVVYIFGNNP VDENGAKIPD EFDNDPILVQ QLRRTYKYFK  120
DYRQMIIEPT SPCLLPDPLQ EPYYQPPYTL VLELTGVLLH PEWSLATGWR FKKRPGIETL  180
FQQLAPLYEI VIFTSETGMT AFPLIDSVDP HGFISYRLFR DATRYMDGHH VKDISCLNRD  240
PARVVVVDCK KEAFRLQPYN GVALRPWDGN SDDRVLLDLS AFLKTIALNG VEDVRTVLEH  300
YALEDDPLAA FKQRQSRLEQ EEQQRLAELS KSNKQNLFLG SLTSRLWPRS KQP         353
FASTA
(Canonical)
>LipidDB-9606-00488|Q3ZCQ8
MAASAAVFSRLRSGLRLGSRGLCTRLATPPRRAPDQAAEIGSRGSTKAQGPQQQPGSEGP
SYAKKVALWLAGLLGAGGTVSVVYIFGNNPVDENGAKIPDEFDNDPILVQQLRRTYKYFK
DYRQMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETL
FQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRD
PARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEH
YALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLGSLTSRLWPRSKQP
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB
GO:0005744; C:mitochondrial inner membrane presequence translocase complex; IPI:UniProtKB
GO:0005739; C:mitochondrion; IDA:HPA
GO:0016607; C:nuclear speck; IDA:UniProtKB
GO:0005134; F:interleukin-2 receptor binding; IDA:MGI
GO:0004721; F:phosphoprotein phosphatase activity; IDA:MGI
GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB
GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB
GO:0043021; F:ribonucleoprotein complex binding; IDA:UniProtKB
GO:0003723; F:RNA binding; IEA:UniProtKB-KW
GO:0044267; P:cellular protein metabolic process; TAS:Reactome
GO:0007006; P:mitochondrial membrane organization; IMP:UniProtKB
GO:0035335; P:peptidyl-tyrosine dephosphorylation; IDA:GOC
GO:0006470; P:protein dephosphorylation; IDA:UniProtKB
GO:0006626; P:protein targeting to mitochondrion; TAS:Reactome
GO:0001836; P:release of cytochrome c from mitochondria; IDA:MGI
Interpro
InterPro; IPR023214; HAD-like_dom
InterPro; IPR004274; NIF
InterPro; IPR027111; Tim50
Pfam
Pfam; PF03031; NIF;
SMART
SMART; SM00577; CPDc;
PROSITE
PROSITE; PS50969; FCP1;
PRINTS