Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00486
Entry Name
UniProt Accession
Theoretical PI
6.09
Molecular Weight
73732.1
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Sn1-specific diacylglycerol lipase beta
Protein Synonyms/Alias
DGL-beta; 3.1.1.-; KCCR13L;
Gene Name
DAGLB
Gene Synonyms/Alias
Created Date
05-SEP-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
78
Canonical
CTVSAIMCVSMRGTI
[1]
S-Palmitoylation
201
Canonical
ETRIKLLCCCIGKDD
[1]
S-Palmitoylation
202
Canonical
TRIKLLCCCIGKDDH
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Sequence Annotation
Topological domain: 1 17 Cytoplasmic.
Transmembrane: 18 38 Helical.
Topological domain: 39 58 Extracellular.
Transmembrane: 59 79 Helical.
Topological domain: 80 102 Cytoplasmic.
Transmembrane: 103 123 Helical.
Topological domain: 124 132 Extracellular.
Transmembrane: 133 153 Helical.
Topological domain: 154 672 Cytoplasmic.
Active site: 443 443 Charge relay system.
Active site: 495 495 Charge relay system.
Modified residue: 570 570 Phosphoserine.
Modified residue: 574 574 Phosphoserine.
Modified residue: 579 579 Phosphoserine.
Modified residue: 584 584 Phosphoserine.
Protein Length
672 AA.
Protein Sequence
(Canonical)
MPGMVLFGRR WAIASDDLVF PGFFELVVRV LWWIGILTLY LMHRGKLDCA GGALLSSYLI  60
VLMILLAVVI CTVSAIMCVS MRGTICNPGP RKSMSKLLYI RLALFFPEMV WASLGAAWVA  120
DGVQCDRTVV NGIIATVVVS WIIIAATVVS IIIVFDPLGG KMAPYSSAGP SHLDSHDSSQ  180
LLNGLKTAAT SVWETRIKLL CCCIGKDDHT RVAFSSTAEL FSTYFSDTDL VPSDIAAGLA  240
LLHQQQDNIR NNQEPAQVVC HAPGSSQEAD LDAELENCHH YMQFAAAAYG WPLYIYRNPL  300
TGLCRIGGDC CRSRTTDYDL VGGDQLNCHF GSILHTTGLQ YRDFIHVSFH DKVYELPFLV  360
ALDHRKESVV VAVRGTMSLQ DVLTDLSAES EVLDVECEVQ DRLAHKGISQ AARYVYQRLI  420
NDGILSQAFS IAPEYRLVIV GHSLGGGAAA LLATMLRAAY PQVRCYAFSP PRGLWSKALQ  480
EYSQSFIVSL VLGKDVIPRL SVTNLEDLKR RILRVVAHCN KPKYKILLHG LWYELFGGNP  540
NNLPTELDGG DQEVLTQPLL GEQSLLTRWS PAYSFSSDSP LDSSPKYPPL YPPGRIIHLQ  600
EEGASGRFGC CSAAHYSAKW SHEAEFSKIL IGPKMLTDHM PDILMRALDS VVSDRAACVS  660
CPAQGVSSVD VA                                                      672
FASTA
(Canonical)
>LipidDB-9606-00486|Q8NCG7
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLI
VLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVA
DGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQ
LLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLA
LLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPL
TGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLV
ALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI
NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQ
EYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNP
NNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQ
EEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVS
CPAQGVSSVDVA
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005765; C:lysosomal membrane; IDA:UniProt
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0019369; P:arachidonic acid metabolic process; IDA:UniProtKB
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW
GO:0007405; P:neuroblast proliferation; IEA:Ensembl
GO:0042136; P:neurotransmitter biosynthetic process; IEA:Ensembl
GO:0030168; P:platelet activation; TAS:Reactome
Interpro
InterPro; IPR029058; AB_hydrolase
InterPro; IPR002921; Fungal_lipase-like
Pfam
Pfam; PF01764; Lipase_3;
SMART
PROSITE
PROSITE; PS00120; LIPASE_SER;
PRINTS