LipidDB ID

LipidDB-9606-00483

Entry Name

UniProt Accession

Q9GZM8; B3KP93; D3DTS0; J3QT32; Q86T80; Q8TAR7; Q9UH50;

Theoretical PI

5.16

Molecular Weight

38374.82

Genbank Protein ID

AAF97497.1; AAG43425.1; AAF24516.3; BAG51605.1; CAD89957.3; EAW90051.1; EAW90052.1; AAH26101.1;

Genbank Nucleotide ID

AY004871; AF182078; AF217798; AK056014; DA256375; AL832648; AC026130; CH471108; CH471108; BC026101;

Protein Name

Nuclear distribution protein nudE-like 1

Protein Synonyms/Alias

Protein Nudel; Mitosin-associated protein 1;

Gene Name

NDEL1

Gene Synonyms/Alias

EOPA; MITAP1; NUDEL;

Created Date

13-JUN-2006

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Shmueli A, Segal M, Sapir T, Tsutsumi R, Noritake J, Bar A, Sapoznik S, FukataY, Orr I, Fukata M, Reiner O. Ndel1 palmitoylation: a new mean to regulatecytoplasmic dynein activity. EMBO J. 2010 Jan 6;29(1):107-19. doi:10.1038/emboj.2009.325. Epub 2009 Nov 19.[PMID:19927128]

Functional Description

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Sequence Annotation

Region: 56 166 Self-association.
Region: 64 189 Interaction with KATNB1.
Region: 114 133 Required for interaction with PAFAH1B1.
Region: 175 345 Interaction with CENPF.
Region: 189 256 Interaction with YWHAE.
Region: 191 345 Interaction with NEFL.
Region: 195 256 Interaction with KATNA1.
Region: 241 280 Interaction with DISC1.
Region: 256 291 Required for localization to thecentrosome and interaction with dynein,dynactin, tubulin gamma, PCM1 and PCNT.
Modified residue: 215 215 Phosphoserine.
Modified residue: 219 219 Phosphothreonine; by CDK1 and MAPK1.
Modified residue: 242 242 Phosphoserine; by CDK1.
Modified residue: 245 245 Phosphothreonine; by CDK1 and MAPK1.

Protein Length

345 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0043203; C:axon hillock; IEA:Ensembl
GO:0031252; C:cell leading edge; IEA:Ensembl
GO:0005813; C:centrosome; IEA:Ensembl
GO:0005737; C:cytoplasm; IDA:HPA
GO:0005829; C:cytosol; TAS:Reactome
GO:0005871; C:kinesin complex; IEA:Ensembl
GO:0000776; C:kinetochore; IDA:UniProtKB
GO:0005874; C:microtubule; IEA:UniProtKB-KW
GO:0060053; C:neurofilament cytoskeleton; IEA:Ensembl
GO:0005635; C:nuclear envelope; IEA:Ensembl
GO:0005730; C:nucleolus; IDA:HPA
GO:0070012; F:oligopeptidase activity; IEA:Ensembl
GO:0032864; P:activation of Cdc42 GTPase activity; IEA:Ensembl
GO:0021955; P:central nervous system neuron axonogenesis; IEA:Ensembl
GO:0051642; P:centrosome localization; IEA:Ensembl
GO:0021799; P:cerebral cortex radially oriented cell migration; IEA:Ensembl
GO:0007059; P:chromosome segregation; IMP:UniProtKB
GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl
GO:0000278; P:mitotic cell cycle; TAS:Reactome
GO:0007100; P:mitotic centrosome separation; IEA:Ensembl
GO:0060052; P:neurofilament cytoskeleton organization; IEA:Ensembl
GO:0001764; P:neuron migration; IEA:Ensembl
GO:1990138; P:neuron projection extension; IEA:Ensembl
GO:0051081; P:nuclear envelope disassembly; IEA:Ensembl
GO:0045773; P:positive regulation of axon extension; IEA:Ensembl
GO:0048680; P:positive regulation of axon regeneration; IEA:Ensembl
GO:0008090; P:retrograde axon cargo transport; IEA:Ensembl
GO:0047496; P:vesicle transport along microtubule; IEA:Ensembl

Interpro

InterPro; IPR006964; NUDE_C

Pfam

Pfam; PF04880; NUDE_C;

SMART

PROSITE

PRINTS