Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00467
Entry Name
UniProt Accession
Theoretical PI
5.19
Molecular Weight
47064.17
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Flotillin-2
Protein Synonyms/Alias
Epidermal surface antigen; ESA; Membrane component chromosome 17 surface marker 1;
Gene Name
FLOT2
Gene Synonyms/Alias
ESA1; M17S1;
Created Date
21-FEB-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
4
Canonical
****MGNCHTVGPNE
[1]
S-Palmitoylation
19
Canonical
ALVVSGGCCGSDYKQ
[1]
S-Palmitoylation
20
Canonical
LVVSGGCCGSDYKQY
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Li Y, Martin BR, Cravatt BF, Hofmann SL. DHHC5 protein palmitoylatesflotillin-2 and is rapidly degraded on induction of neuronal differentiation incultured cells. J Biol Chem. 2012 Jan 2;287(1):523-30. doi:10.1074/jbc.M111.306183. Epub 2011 Nov 11.[PMID:22081607]
Functional Description
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
Sequence Annotation
Protein Length
428 AA.
Protein Sequence
(Canonical)
MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRISLEIM TLQPRCEDVE  60
TAEGVALTVT GVAQVKIMTE KELLAVACEQ FLGKNVQDIK NVVLQTLEGH LRSILGTLTV  120
EQIYQDRDQF AKLVREVAAP DVGRMGIEIL SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD  180
IGVAEAERDA GIREAECKKE MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA  240
YELQGAREQQ KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRRPA EAEAHRIQQI  300
AEGEKVKQVL LAQAEAEKIR KIGEAEAAVI EAMGKAEAER MKLKAEAYQK YGDAAKMALV  360
LEALPQIAAK IAAPLTKVDE IVVLSGDNSK VTSEVNRLLA ELPASVHALT GVDLSKIPLI  420
KKATGVQV                                                           428
FASTA
(Canonical)
>LipidDB-9606-00467|Q14254
MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVE
TAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTV
EQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDAD
IGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLA
YELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQI
AEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALV
LEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLI
KKATGVQV
Gene Ontology
GO:0002080; C:acrosomal membrane; IEA:Ensembl
GO:0005901; C:caveola; IDA:MGI
GO:0030139; C:endocytic vesicle; IDA:UniProtKB
GO:0005768; C:endosome; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB
GO:0016600; C:flotillin complex; IEA:Ensembl
GO:0005925; C:focal adhesion; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProt
GO:0005886; C:plasma membrane; NAS:ProtInc
GO:0031982; C:vesicle; IDA:UniProt
GO:0007155; P:cell adhesion; NAS:ProtInc
GO:0008544; P:epidermis development; TAS:ProtInc
GO:0090002; P:establishment of protein localization to plasma membrane; IMP:UniProtKB
GO:1902992; P:negative regulation of amyloid precursor protein catabolic process; IMP:UniProtKB
GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB
GO:0050821; P:protein stabilization; IMP:UniProtKB
Interpro
InterPro; IPR001107; Band_7
InterPro; IPR027705; Flotillin_fam
Pfam
Pfam; PF01145; Band_7;
SMART
SMART; SM00244; PHB;
PROSITE
PRINTS