Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00465
Entry Name
UniProt Accession
Theoretical PI
5.58
Molecular Weight
80495.37
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Disks large homolog 4
Protein Synonyms/Alias
Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90;
Gene Name
DLG4
Gene Synonyms/Alias
PSD95;
Created Date
01-NOV-1997
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
3
Canonical
*****MDCLCIVTTK
[1]
S-Palmitoylation
5
Canonical
***MDCLCIVTTKKY
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Zheng CY, Petralia RS, Wang YX, Kachar B, Wenthold RJ. SAP102 is a highlymobile MAGUK in spines. J Neurosci. 2010 Mar 31;30(13):4757-66. doi:10.1523/JNEUROSCI.6108-09.2010.[PMID:20357126]
Functional Description
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
Sequence Annotation
Domain: 65 151 PDZ 1.
Domain: 160 246 PDZ 2.
Domain: 313 393 PDZ 3.
Domain: 428 498 SH3.
Domain: 534 709 Guanylate kinase-like.
Modified residue: 142 142 Phosphoserine.
Modified residue: 240 240 Phosphotyrosine.
Modified residue: 580 580 Phosphotyrosine.
Modified residue: 715 715 Phosphotyrosine.
Protein Length
724 AA.
Protein Sequence
(Canonical)
MDCLCIVTTK KYRYQDEDTP PLEHSPAHLP NQANSPPVIV NTDTLEAPGY ELQVNGTEGE  60
MEYEEITLER GNSGLGFSIA GGTDNPHIGD DPSIFITKII PGGAAAQDGR LRVNDSILFV  120
NEVDVREVTH SAAVEALKEA GSIVRLYVMR RKPPAEKVME IKLIKGPKGL GFSIAGGVGN  180
QHIPGDNSIY VTKIIEGGAA HKDGRLQIGD KILAVNSVGL EDVMHEDAVA ALKNTYDVVY  240
LKVAKPSNAY LSDSYAPPDI TTSYSQHLDN EISHSSYLGT DYPTAMTPTS PRRYSPVAKD  300
LLGEEDIPRE PRRIVIHRGS TGLGFNIVGG EDGEGIFISF ILAGGPADLS GELRKGDQIL  360
SVNGVDLRNA SHEQAAIALK NAGQTVTIIA QYKPEEYSRF EAKIHDLREQ LMNSSLGSGT  420
ASLRSNPKRG FYIRALFDYD KTKDCGFLSQ ALSFRFGDVL HVIDASDEEW WQARRVHSDS  480
ETDDIGFIPS KRRVERREWS RLKAKDWGSS SGSQGREDSV LSYETVTQME VHYARPIIIL  540
GPTKDRANDD LLSEFPDKFG SCVPHTTRPK REYEIDGRDY HFVSSREKME KDIQAHKFIE  600
AGQYNSHLYG TSVQSVREVA EQGKHCILDV SANAVRRLQA AHLHPIAIFI RPRSLENVLE  660
INKRITEEQA RKAFDRATKL EQEFTECFSA IVEGDSFEEI YHKVKRVIED LSGPYIWVPA  720
RERL                                                               724
FASTA
(Canonical)
>LipidDB-9606-00465|P78352
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGE
MEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFV
NEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGN
QHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVY
LKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKD
LLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQIL
SVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGT
ASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDS
ETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIIL
GPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIE
AGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLE
INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPA
RERL
Gene Ontology
GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; ISS:BHF-UCL
GO:0030054; C:cell junction; ISS:BHF-UCL
GO:0044300; C:cerebellar mossy fiber; IEA:Ensembl
GO:0030863; C:cortical cytoskeleton; IDA:UniProtKB
GO:0005737; C:cytoplasm; ISS:BHF-UCL
GO:0032839; C:dendrite cytoplasm; ISS:BHF-UCL
GO:0043197; C:dendritic spine; ISS:ParkinsonsUK-UCL
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome
GO:0005783; C:endoplasmic reticulum; ISS:BHF-UCL
GO:0060076; C:excitatory synapse; ISS:BHF-UCL
GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:BHF-UCL
GO:0044224; C:juxtaparanode region of axon; ISS:BHF-UCL
GO:0044306; C:neuron projection terminus; ISS:BHF-UCL
GO:0044309; C:neuron spine; ISS:BHF-UCL
GO:0097481; C:neuronal postsynaptic density; ISS:BHF-UCL
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0014069; C:postsynaptic density; ISS:UniProtKB
GO:0045211; C:postsynaptic membrane; IDA:UniProtKB
GO:0045202; C:synapse; IDA:BHF-UCL
GO:0008021; C:synaptic vesicle; ISS:BHF-UCL
GO:0033130; F:acetylcholine receptor binding; ISS:BHF-UCL
GO:0031697; F:beta-1 adrenergic receptor binding; ISS:BHF-UCL
GO:0031748; F:D1 dopamine receptor binding; ISS:BHF-UCL
GO:0035255; F:ionotropic glutamate receptor binding; ISS:BHF-UCL
GO:0031812; F:P2Y1 nucleotide receptor binding; ISS:BHF-UCL
GO:0030165; F:PDZ domain binding; ISS:BHF-UCL
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB
GO:0032403; F:protein complex binding; ISS:BHF-UCL
GO:0019903; F:protein phosphatase binding; ISS:BHF-UCL
GO:0097110; F:scaffold protein binding; ISS:BHF-UCL
GO:0097113; P:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering; ISS:BHF-UCL
GO:0007411; P:axon guidance; TAS:Reactome
GO:0060997; P:dendritic spine morphogenesis; ISS:BHF-UCL
GO:0045184; P:establishment of protein localization; IDA:BHF-UCL
GO:0007612; P:learning; TAS:ProtInc
GO:0035641; P:locomotory exploration behavior; IEA:Ensembl
GO:0002091; P:negative regulation of receptor internalization; ISS:BHF-UCL
GO:0007399; P:nervous system development; TAS:ProtInc
GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl
GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:BHF-UCL
GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL
GO:0050806; P:positive regulation of synaptic transmission; ISS:BHF-UCL
GO:0006461; P:protein complex assembly; IDA:BHF-UCL
GO:0035418; P:protein localization to synapse; IDA:BHF-UCL
GO:0097120; P:receptor localization to synapse; ISS:BHF-UCL
GO:2000821; P:regulation of grooming behavior; IEA:Ensembl
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; ISS:BHF-UCL
GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:BHF-UCL
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0035176; P:social behavior; IEA:Ensembl
GO:0007268; P:synaptic transmission; TAS:Reactome
GO:0016188; P:synaptic vesicle maturation; ISS:BHF-UCL
GO:0071625; P:vocalization behavior; IEA:Ensembl
Interpro
InterPro; IPR016313; DLG1
InterPro; IPR008145; GK/Ca_channel_bsu
InterPro; IPR008144; Guanylate_kin-like
InterPro; IPR020590; Guanylate_kinase_CS
InterPro; IPR019590; MAGUK_PEST_N
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR001478; PDZ
InterPro; IPR019583; PDZ_assoc
InterPro; IPR001452; SH3_domain
Pfam
Pfam; PF00625; Guanylate_kin;
Pfam; PF10608; MAGUK_N_PEST;
Pfam; PF00595; PDZ;
Pfam; PF10600; PDZ_assoc;
Pfam; PF00018; SH3_1;
SMART
SMART; SM00072; GuKc;
SMART; SM00228; PDZ;
SMART; SM00326; SH3;
PROSITE
PROSITE; PS00856; GUANYLATE_KINASE_1;
PROSITE; PS50052; GUANYLATE_KINASE_2;
PROSITE; PS50106; PDZ;
PROSITE; PS50002; SH3;
PRINTS