LipidDB ID

LipidDB-9606-00457

Entry Name

UniProt Accession

Q29983; A8KQR0; A9LRW5; A9QVE0; B1VJF1; O60917; O60918; O60919; O60920; O60933; O77956; O78150; O78151; O78152; O78153; O97987; O97988; O97989; O97990; O97991; O97992; O97993; O97994; O97995; O98234; O98235; O98236; O98237; O98238; P79506; P79507; P79508; P79509; P79510; P79511; P79512; P79513; P79514; P79515; P79516; P79517; P79518; P79519; P79520; P79521; Q5C9P8; Q5XM81; Q70I48; Q70I49; Q7JFH9; Q7JFI0; Q7JFI1; Q7JFI2; Q7YQ98; Q861I1; Q95464; Q95HA2; Q95HD6; Q95HN4; Q95HN5; Q95HN6; Q95IB2; Q95IY7; Q99692; Q9BCR3; Q9BCR4; Q9BCR5; Q9BCR6; Q9BCR7; Q9BCR8; Q9BCR9; Q9BCS0; Q9BCS1; Q9BCS2; Q9BCS3; Q9BCS4; Q9BD20; Q9GIZ1; Q9GIZ2; Q9GIZ3; Q9GIZ4; Q9GIZ5; Q9GIZ6; Q9GJ01; Q9GJ02; Q9GJ03; Q9GJ04; Q9GJ05; Q9GJ06; Q9GJ07; Q9GJ08; Q9GJ09; Q9MY21; Q9TQ86; Q9TQ87; Q9TQ88; Q9TQ89; Q9TQ92; Q9TQ93; Q9TQ94; Q9TQ95; Q9TQ96; Q9TQ97; Q9TQ98; Q9TQ99; Q9TQA0; Q9TQA1; Q9TQA2; Q9TQA3; Q9TQA4; Q9TQI9; Q9TQJ0; Q9TQJ1; Q9TQJ9; Q9TQK0; Q9TQK1; Q9TQK2; Q9TQK8; Q9TQK9; Q9TQL0; Q9TQL1; Q9TQL2; Q9TQL3; Q9TQL4; Q9UE04; Q9UE05; Q9UE06; Q9UE11;

Theoretical PI

6.49

Molecular Weight

42915.4

Genbank Protein ID

AAA21718.1; CAA63427.1; CAI41907.1; CAQ11015.1; AAH16929.1; AAB41060.1; AAB41061.1; AAB41062.1; AAB41063.1; AAB41064.1; AAB41065.1; AAB41066.1; AAB41067.1; AAB41068.1; AAB41069.1; AAB41070.1; AAB41071.1; AAB41072.1; AAB41073.1; AAB41074.1; AAB41075.1; CAA76393.1; CAA76394.1; CAA76395.1; CAA76396.1; CAA76397.1; CAA76398.1; CAA76399.1; CAA76400.1; CAA76401.1; CAA76402.1; CAA76403.1; CAA77029.1; CAA77030.1; CAA77031.1; AAD27006.1; AAD27007.1; AAD27008.1; AAD27009.1; BAA29034.1; CAD91415.1; AAD01474.1; AAD01476.1; AAD01477.1; AAD01479.1; AAD01480.1; AAD01492.1; AAD01481.1; AAD01482.1; AAD01483.1; AAD01484.1; AAD01485.1; AAD01486.1; AAD01488.1; AAD01489.1; AAD01490.1; AAD01491.1; AAD52060.1; AAD52061.1; AAD52062.1; AAD52063.1; AAD52064.1; AAD52065.1; AAD52066.1; AAD52067.1; AAD52068.1; AAD52069.1; AAD52070.1; AAD52071.1; AAD52072.1; AAD01475.1; AAD01478.1; AAD01473.1; AAD01487.1; AAK58536.1; AAL13171.1; AAK58537.1; AAK58538.1; AAK19622.1; AAK17997.1; AAK25770.1; AAK25771.1; AAK18281.1; AAK19623.1; AAK20897.1; AAK20898.1; AAK27364.1; AAK20899.1; AAK26323.1; AAK26324.1; AAK51140.1; CAC14280.1; CAC14281.1; CAC14282.1; CAC14283.1; CAC14284.1; CAC14285.1; CAC14286.1; CAC14287.1; CAC14288.1; CAC15380.1; CAC15381.1; CAC15382.1; CAC15383.1; CAC16142.1; CAC16143.1; CAC27561.1; AAV39504.1; CAB71317.1; CAC88121.1; CAC88121.1; CAE45581.1; CAE45582.2; AAU95382.1; CAP12057.1; ABX54884.1; CAQ16171.1; AAC28941.1; AAC28942.1; AAC28943.1; AAC28944.1; AAC28945.1; AAD19598.1; AAD19599.1; AAD19600.1; AAD19601.1; AAD19602.1; AAD19603.1; AAD19604.1; AAD19604.1; AAD19604.1; AAD19605.1; ABX60404.1; AAM34484.1;

Genbank Nucleotide ID

L14848; X92841; AL845443; CR847852; BC016929; BG114064; L29406; L29408; L29409; L29411; U56940; U56941; U56942; U56943; U56944; U56945; U56946; U56947; U56948; U56949; U56950; U56951; U56952; U56953; U56954; U56955; Y16801; Y16802; Y16803; Y16804; Y16805; Y16806; Y16807; Y16808; Y16809; Y16810; Y16811; Y18110; Y18111; Y18112; AF097403; AF097404; AF097405; AF097406; AB015600; AJ563426; AH007168; AH007170; AH007171; AH007173; AH007174; AH007186; AH007175; AH007176; AH007177; AH007178; AH007179; AH007180; AH007182; AH007183; AH007184; AH007185; AH008136; AH008137; AH008138; AH008139; AH008140; AH008141; AH008142; AH008143; AH008144; AH008145; AH008146; AH008147; AH008148; AH007169; AH007172; AH007167; AH007181; AH010819; AH011143; AH010820; AH010821; AH010545; AH010526; AH010568; AH010569; AH010532; AH010546; AH010560; AH010561; AH010587; AH010562; AH010571; AH010572; AH010740; AJ250499; AJ250500; AJ250501; AJ250502; AJ250503; AJ250504; AJ250505; AJ250506; AJ250507; AJ250802; AJ250803; AJ250804; AJ250805; AJ250990; AJ250991; AJ271789; AY603357; AJ249394; AJ295250; AJ295251; AJ580805; AJ580806; AH014149; AM899996; EU254723; AM944063; AH006330; AH006331; AH006332; AH006333; AH006334; AH007472; AH007473; AH007474; AH007475; AH007476; AH007477; AF106652; AF106650; AF106651; AH007479; EU267602; AY095537;

Protein Name

MHC class I polypeptide-related sequence A

Protein Synonyms/Alias

MIC-A;

Gene Name

MICA

Gene Synonyms/Alias

PERB11.1;

Created Date

20-MAY-2008

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Agüera-González S, Gross CC, Fernández-Messina L, Ashiru O, Esteso G, Hang HC,Reyburn HT, Long EO, Valés-Gómez M. Palmitoylation of MICA, a ligand for NKG2D,mediates its recruitment to membrane microdomains and promotes its shedding. Eur J Immunol. 2011 Dec;41(12):3667-76. doi: 10.1002/eji.201141645. Epub 2011 Nov 3.[PMID:21928280]

Functional Description

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Sequence Annotation

Topological domain: 24 307 Extracellular.
Transmembrane: 308 328 Helical.
Topological domain: 329 383 Cytoplasmic.
Domain: 207 296 Ig-like C1-type.

Protein Length

383 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0009986; C:cell surface; IDA:UniProtKB
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0005615; C:extracellular space; IDA:BHF-UCL
GO:0005887; C:integral component of plasma membrane; IDA:BHF-UCL
GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:UniProtKB
GO:0019882; P:antigen processing and presentation; IEA:InterPro
GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB
GO:0019835; P:cytolysis; IEA:UniProtKB-KW
GO:0042742; P:defense response to bacterium; IDA:UniProtKB
GO:0051607; P:defense response to virus; IDA:UniProtKB
GO:0046629; P:gamma-delta T cell activation; IDA:UniProtKB
GO:0002418; P:immune response to tumor cell; IDA:UniProtKB
GO:0042267; P:natural killer cell mediated cytotoxicity; IDA:UniProtKB
GO:0009408; P:response to heat; IDA:UniProtKB
GO:0001913; P:T cell mediated cytotoxicity; IDA:UniProtKB
GO:0016032; P:viral process; IEA:UniProtKB-KW

Interpro

InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003597; Ig_C1-set
InterPro; IPR011161; MHC_I-like_Ag-recog
InterPro; IPR011162; MHC_I/II-like_Ag-recog
InterPro; IPR001039; MHC_I_a_a1/a2

Pfam

Pfam; PF07654; C1-set;
Pfam; PF00129; MHC_I;

SMART

SMART; SM00407; IGc1;

PROSITE

PROSITE; PS50835; IG_LIKE;

PRINTS