LipidDB ID

LipidDB-9606-00446

Entry Name

UniProt Accession

P11488; Q4VBN2;

Theoretical PI

5.4

Molecular Weight

40040.79

Genbank Protein ID

CAB37839.2; CAA33196.1; AAM12622.1; AAB54048.1; AAH95505.1;

Genbank Nucleotide ID

X63749; X15088; AF493908; AC002077; BC095505;

Protein Name

Guanine nucleotide-binding protein G(t) subunit alpha-1

Protein Synonyms/Alias

Transducin alpha-1 chain;

Gene Name

GNAT1

Gene Synonyms/Alias

GNATR;

Created Date

01-OCT-1989

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R,Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W. UNC119 is required for G protein trafficking in sensory neurons.Nat Neurosci. 2011 Jun 5;14(7):874-80. doi: 10.1038/nn.2835.[PMID:21642972]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.

Sequence Annotation

Nucleotide-binding: 36 43 GTP.
Nucleotide-binding: 171 177 GTP.
Nucleotide-binding: 196 200 GTP.
Nucleotide-binding: 265 268 GTP.
Metal binding site: 43 43 Magnesium.
Metal binding site: 177 177 Magnesium.
Binding site: 322 322 GTP; via amide nitrogen.
Modified residue: 142 142 Phosphotyrosine; by SRC.
Modified residue: 174 174 ADP-ribosylarginine; by cholera toxin.
Modified residue: 347 347 ADP-ribosylcysteine; by pertussis toxin.

Protein Length

350 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016324; C:apical plasma membrane; IEA:Ensembl
GO:0005829; C:cytosol; TAS:Reactome
GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome
GO:0016020; C:membrane; NAS:UniProtKB
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0032391; C:photoreceptor connecting cilium; IEA:Ensembl
GO:0097381; C:photoreceptor disc membrane; TAS:Reactome
GO:0001917; C:photoreceptor inner segment; IDA:UniProtKB
GO:0001750; C:photoreceptor outer segment; IDA:UniProtKB
GO:0042622; C:photoreceptor outer segment membrane; ISS:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0000035; F:acyl binding; ISS:UniProtKB
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome
GO:0019003; F:GDP binding; ISS:UniProtKB
GO:0005525; F:GTP binding; ISS:UniProtKB
GO:0003924; F:GTPase activity; NAS:UniProtKB
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0019901; F:protein kinase binding; ISS:UniProtKB
GO:0004871; F:signal transducer activity; IBA:RefGenome
GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome
GO:0008283; P:cell proliferation; IEA:Ensembl
GO:0071257; P:cellular response to electrical stimulus; IEA:Ensembl
GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IEA:Ensembl
GO:0050908; P:detection of light stimulus involved in visual perception; IMP:UniProtKB
GO:0042462; P:eye photoreceptor cell development; IEA:Ensembl
GO:0051344; P:negative regulation of cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB
GO:0007603; P:phototransduction, visible light; IMP:UniProtKB
GO:0051343; P:positive regulation of cyclic-nucleotide phosphodiesterase activity; IEA:Ensembl
GO:0022400; P:regulation of rhodopsin mediated signaling pathway; TAS:Reactome
GO:0009642; P:response to light intensity; IEA:Ensembl
GO:0009416; P:response to light stimulus; ISS:UniProtKB
GO:0060041; P:retina development in camera-type eye; IEA:Ensembl
GO:0016056; P:rhodopsin mediated signaling pathway; TAS:Reactome
GO:0050917; P:sensory perception of umami taste; IBA:RefGenome
GO:0007165; P:signal transduction; NAS:UniProtKB
GO:0007601; P:visual perception; TAS:UniProtKB

Interpro

InterPro; IPR001408; Gprotein_alpha_I
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase

Pfam

Pfam; PF00503; G-alpha;

SMART

SMART; SM00275; G_alpha;

PROSITE

PRINTS

PRINTS; PR00318; GPROTEINA;
PRINTS; PR00441; GPROTEINAI;