LipidDB ID

LipidDB-9606-00440

Entry Name

UniProt Accession

P62820; P11476; Q6FIE7; Q96N61; Q9Y3T2;

Theoretical PI

5.93

Molecular Weight

22677.75

Genbank Protein ID

AAA60240.1; CAB43369.1; CAE11872.1; BAB71048.1; AAM21077.1; CAG38510.1; EAW99921.1; AAH00905.1;

Genbank Nucleotide ID

M28209; AL050268; BX571747; AK055927; AF498929; CR533479; CH471053; BC000905;

Protein Name

Ras-related protein Rab-1A

Protein Synonyms/Alias

YPT1-related protein;

Gene Name

RAB1A

Gene Synonyms/Alias

RAB1;

Created Date

16-AUG-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Farnsworth CC, Seabra MC, Ericsson LH, Gelb MH, Glomset JA. Rab geranylgeranyltransferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. Proc Natl Acad Sci U S A. 1994 Dec6;91(25):11963-7.[PMID:7991565]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

Sequence Annotation

Nucleotide-binding: 18 26 GTP.
Nucleotide-binding: 36 43 GTP.
Nucleotide-binding: 66 70 GTP.
Nucleotide-binding: 124 127 GTP.
Nucleotide-binding: 154 156 GTP.
Motif: 40 48 Effector region.
Modified residue: 2 2 N-acetylserine.
Modified residue: 79 79 O-(2-cholinephosphoryl)serine; byLegionella AnkX.
Modified residue: 194 194 Phosphoserine; by CDK1.

Protein Length

205 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0000139; C:Golgi membrane; TAS:Reactome
GO:0042470; C:melanosome; IEA:Ensembl
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0000045; P:autophagic vacuole assembly; IMP:UniProtKB
GO:0006914; P:autophagy; IMP:UniProtKB
GO:0090110; P:cargo loading into COPII-coated vesicle; IMP:UniProtKB
GO:0016477; P:cell migration; IMP:UniProtKB
GO:0042742; P:defense response to bacterium; IMP:UniProtKB
GO:0006897; P:endocytosis; IMP:UniProtKB
GO:0006888; P:ER to Golgi vesicle-mediated transport; IMP:UniProtKB
GO:0007030; P:Golgi organization; IMP:UniProtKB
GO:0030252; P:growth hormone secretion; IMP:UniProtKB
GO:0006184; P:GTP catabolic process; IDA:UniProtKB
GO:0072606; P:interleukin-8 secretion; IMP:UniProtKB
GO:0032402; P:melanosome transport; IEA:Ensembl
GO:0000278; P:mitotic cell cycle; TAS:Reactome
GO:1903020; P:positive regulation of glycoprotein metabolic process; IGI:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl
GO:0047496; P:vesicle transport along microtubule; IMP:UniProtKB
GO:0016192; P:vesicle-mediated transport; TAS:ProtInc
GO:0019068; P:virion assembly; IMP:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;