LipidDB ID

LipidDB-9606-00439

Entry Name

UniProt Accession

P02730; G4V2I6; P78487; Q1ZZ45; Q4KKW9; Q4VB84; Q9UCY7; Q9UDJ1;

Theoretical PI

5.08

Molecular Weight

101792.33

Genbank Protein ID

CAA31128.1; AAA35514.1; ABD74692.1; ADN39420.1; ADN39421.1; AAY57324.1; EAW51614.1; AAH96106.1; AAH96107.1; AAH99628.1; AAH99629.1; AAI01571.1; AAI01575.1; AAC60608.2;

Genbank Nucleotide ID

X12609; M27819; DQ419529; GQ981383; GQ981384; DQ072115; CH471178; BC096106; BC096107; BC099628; BC099629; BC101570; BC101574; S68680;

Protein Name

Band 3 anion transport protein

Protein Synonyms/Alias

Anion exchange protein 1; AE 1; Anion exchanger 1; Solute carrier family 4 member 1; CD233;

Gene Name

SLC4A1

Gene Synonyms/Alias

AE1; DI; EPB3;

Created Date

21-JUL-1986

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Cheung JC, Reithmeier RA. Palmitoylation is not required for trafficking ofhuman anion exchanger 1 to the cell surface. Biochem J. 2004 Mar 15;378(Pt3):1015-21.[PMID:14640982]

Functional Description

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.

Sequence Annotation

Topological domain: 1 403 Cytoplasmic.
Transmembrane: 404 424 Helical.
Transmembrane: 437 456 Helical.
Transmembrane: 460 479 Helical.
Transmembrane: 491 510 Helical.
Transmembrane: 523 541 Helical.
Topological domain: 542 568 Extracellular.
Transmembrane: 569 588 Helical.
Topological domain: 589 603 Cytoplasmic.
Transmembrane: 604 624 Helical.
Topological domain: 625 660 Extracellular.
Transmembrane: 661 680 Helical.
Transmembrane: 699 719 Helical.
Transmembrane: 763 780 Helical.
Transmembrane: 785 806 Helical.
Transmembrane: 844 865 Helical.
Region: 55 290 Globular.
Region: 176 185 Interaction with ANK1.
Region: 304 357 Dimerization arm.
Region: 404 911 Membrane (anion exchange).
Region: 559 630 Involved in anion transport.
Functional site: 590 590 Important for anion transport.
Functional site: 681 681 Important for anion-proton cotransport.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 8 8 Phosphotyrosine.
Modified residue: 21 21 Phosphotyrosine.
Modified residue: 46 46 Phosphotyrosine.
Modified residue: 359 359 Phosphotyrosine.
Modified residue: 904 904 Phosphotyrosine.

Protein Length

911 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB
GO:0072562; C:blood microparticle; IDA:UniProt
GO:0030863; C:cortical cytoskeleton; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; NAS:UniProtKB
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0030018; C:Z disc; ISS:UniProtKB
GO:0008509; F:anion transmembrane transporter activity; TAS:ProtInc
GO:0015301; F:anion:anion antiporter activity; IDA:UniProtKB
GO:0030506; F:ankyrin binding; IPI:BHF-UCL
GO:0015106; F:bicarbonate transmembrane transporter activity; IDA:UniProtKB
GO:0015108; F:chloride transmembrane transporter activity; ISS:UniProtKB
GO:0005452; F:inorganic anion exchanger activity; IDA:UniProtKB
GO:0043495; F:protein anchor; TAS:BHF-UCL
GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL
GO:0006820; P:anion transport; IDA:UniProtKB
GO:0015701; P:bicarbonate transport; IDA:UniProtKB
GO:0006873; P:cellular ion homeostasis; TAS:ProtInc
GO:0006821; P:chloride transport; ISS:UniProtKB
GO:0006811; P:ion transport; TAS:Reactome
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0055085; P:transmembrane transport; TAS:Reactome

Interpro

InterPro; IPR001717; Anion_exchange
InterPro; IPR002977; Anion_exchange_1
InterPro; IPR018241; Anion_exchange_CS
InterPro; IPR013769; Band3_cytoplasmic_dom
InterPro; IPR011531; HCO3_transpt_C
InterPro; IPR003020; HCO3_transpt_euk
InterPro; IPR016152; PTrfase/Anion_transptr

Pfam

Pfam; PF07565; Band_3_cyto;
Pfam; PF00955; HCO3_cotransp;

SMART

PROSITE

PROSITE; PS00219; ANION_EXCHANGER_1;
PROSITE; PS00220; ANION_EXCHANGER_2;

PRINTS

PRINTS; PR00165; ANIONEXCHNGR;
PRINTS; PR01187; ANIONEXHNGR1;
PRINTS; PR01231; HCO3TRNSPORT;