Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00435
Entry Name
UniProt Accession
Theoretical PI
5.57
Molecular Weight
40460.08
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
HLA class I histocompatibility antigen, B-7 alpha chain
Protein Synonyms/Alias
MHC class I antigen B*7;
Gene Name
HLA-B
Gene Synonyms/Alias
HLAB;
Created Date
21-JUL-1986
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
332
Canonical
AVVAAVMCRRKSSGG
[1]
S-Palmitoylation
349
Canonical
GSYSQAACSDSAQGS
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Gruda R, Achdout H, Stern-Ginossar N, Gazit R, Betser-Cohen G, Manaster I,Katz G, Gonen-Gross T, Tirosh B, Mandelboim O. Intracellular cysteine residues inthe tail of MHC class I proteins are crucial for extracellular recognition byleukocyte Ig-like receptor 1. J Immunol. 2007 Sep 15;179(6):3655-61.[PMID:17785801]
Functional Description
Involved in the presentation of foreign antigens to the immune system.
Sequence Annotation
Topological domain: 25 309 Extracellular.
Transmembrane: 310 333 Helical.
Topological domain: 334 362 Cytoplasmic.
Domain: 209 295 Ig-like C1-type.
Region: 25 114 Alpha-1.
Region: 115 206 Alpha-2.
Region: 207 298 Alpha-3.
Region: 299 309 Connecting peptide.
Protein Length
362 AA.
Protein Sequence
(Canonical)
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF  60
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ  120
SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR  180
RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT  240
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP  300
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL  360
TA                                                                 362
FASTA
(Canonical)
>LipidDB-9606-00435|P01889
MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRF
DSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQ
SMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQR
RAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLT
WQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP
SSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSL
TA
Gene Ontology
GO:0009986; C:cell surface; ISS:UniProt
GO:0031901; C:early endosome membrane; TAS:Reactome
GO:0005783; C:endoplasmic reticulum; IDA:UniProt
GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:UniProt
GO:0000139; C:Golgi membrane; TAS:Reactome
GO:0071556; C:integral component of lumenal side of endoplasmic reticulum membrane; TAS:Reactome
GO:0005887; C:integral component of plasma membrane; NAS:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0042612; C:MHC class I protein complex; ISS:UniProt
GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0042605; F:peptide antigen binding; ISS:UniProt
GO:0005102; F:receptor binding; IPI:BHF-UCL
GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAS:Reactome
GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome
GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome
GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome
GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome
GO:0006955; P:immune response; NAS:UniProtKB
GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome
GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:InterPro
GO:0042270; P:protection from natural killer cell mediated cytotoxicity; IDA:UniProt
GO:2001198; P:regulation of dendritic cell differentiation; IMP:BHF-UCL
GO:0050776; P:regulation of immune response; TAS:Reactome
GO:0032655; P:regulation of interleukin-12 production; IMP:BHF-UCL
GO:0032675; P:regulation of interleukin-6 production; IMP:BHF-UCL
GO:0002667; P:regulation of T cell anergy; IMP:BHF-UCL
GO:0060337; P:type I interferon signaling pathway; TAS:Reactome
GO:0016032; P:viral process; IEA:UniProtKB-KW
Interpro
InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003006; Ig/MHC_CS
InterPro; IPR003597; Ig_C1-set
InterPro; IPR011161; MHC_I-like_Ag-recog
InterPro; IPR011162; MHC_I/II-like_Ag-recog
InterPro; IPR027648; MHC_I_a
InterPro; IPR001039; MHC_I_a_a1/a2
InterPro; IPR010579; MHC_I_a_C
Pfam
Pfam; PF07654; C1-set;
Pfam; PF00129; MHC_I;
Pfam; PF06623; MHC_I_C;
SMART
SMART; SM00407; IGc1;
PROSITE
PROSITE; PS50835; IG_LIKE;
PROSITE; PS00290; IG_MHC;
PRINTS
PRINTS; PR01638; MHCCLASSI;