LipidDB ID

LipidDB-9606-00428

Entry Name

UniProt Accession

Q86XR7; B3Y698; Q6JUT2;

Theoretical PI

4.99

Molecular Weight

26916.13

Genbank Protein ID

AAP81748.1; BAC98399.1; BAC98397.1; AAO74498.1; AAQ97430.1; AAQ97431.1; AAQ97432.1; AAQ97433.1; BAG55268.1; BAC77375.1; EAW48960.1; EAW48961.1; AAI09266.1; AAI09267.1;

Genbank Nucleotide ID

AY275836; AB109098; AB091054; AY232653; AY304581; AY304582; AY304583; AY304584; AB446491; AB097022; AC010226; CH471086; CH471086; BC109265; BC109266;

Protein Name

TIR domain-containing adapter molecule 2

Protein Synonyms/Alias

TICAM-2; Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4;

Gene Name

TICAM2

Gene Synonyms/Alias

TIRAP3; TIRP; TRAM;

Created Date

05-FEB-2008

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'NeillLA, Fitzgerald KA, Golenbock DT. The myristoylation of TRIF-related adaptormolecule is essential for Toll-like receptor 4 signal transduction. Proc NatlAcad Sci U S A. 2006 Apr 18;103(16):6299-304. Epub 2006 Apr 7.[PMID:16603631]

Functional Description

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.

Sequence Annotation

Domain: 73 232 TIR.
Modified residue: 16 16 Phosphoserine; by PKC/PRKCE.

Protein Length

235 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005769; C:early endosome; IDA:UniProtKB
GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB
GO:0010008; C:endosome membrane; TAS:Reactome
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0005770; C:late endosome; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005543; F:phospholipid binding; IEA:Ensembl
GO:0004871; F:signal transducer activity; IMP:UniProtKB
GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB
GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; TAS:Reactome
GO:0006954; P:inflammatory response; IEA:UniProtKB-KW
GO:0045087; P:innate immune response; TAS:Reactome
GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; TAS:Reactome
GO:0071650; P:negative regulation of chemokine (C-C motif) ligand 5 production; IMP:UniProtKB
GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IDA:UniProtKB
GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IEA:Ensembl
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB
GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl
GO:2000494; P:positive regulation of interleukin-18-mediated signaling pathway; IMP:UniProtKB
GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl
GO:0034145; P:positive regulation of toll-like receptor 4 signaling pathway; IDA:UniProtKB
GO:0070671; P:response to interleukin-12; IEA:Ensembl
GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome
GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome
GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome
GO:0035669; P:TRAM-dependent toll-like receptor 4 signaling pathway; IDA:UniProtKB
GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome

Interpro

InterPro; IPR000157; TIR_dom
InterPro; IPR015720; TMP21-related

Pfam

Pfam; PF13676; TIR_2;

SMART

PROSITE

PROSITE; PS50104; TIR;

PRINTS