Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00425
Entry Name
UniProt Accession
Theoretical PI
8.32
Molecular Weight
65990.97
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
G protein-coupled receptor kinase 6
Protein Synonyms/Alias
2.7.11.16; G protein-coupled receptor kinase GRK6;
Gene Name
GRK6
Gene Synonyms/Alias
GPRK6;
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
561
Canonical
RLFSRQDCCGNCSDS
[1]
S-Palmitoylation
562
Canonical
LFSRQDCCGNCSDSE
[1]
S-Palmitoylation
565
Canonical
RQDCCGNCSDSEEEL
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Jiang X, Benovic JL, Wedegaertner PB. Plasma membrane and nuclear localizationof G protein coupled receptor kinase 6A. Mol Biol Cell. 2007 Aug;18(8):2960-9.Epub 2007 May 30.[PMID:17538017]
Functional Description
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Sequence Annotation
Domain: 53 171 RGS.
Domain: 186 448 Protein kinase.
Domain: 449 514 AGC-kinase C-terminal.
Nucleotide-binding: 192 200 ATP.
Nucleotide-binding: 264 270 ATP.
Nucleotide-binding: 315 318 ATP.
Region: 1 185 N-terminal.
Active site: 311 311 Proton acceptor.
Binding site: 215 215 ATP.
Modified residue: 484 484 Phosphoserine.
Modified residue: 485 485 Phosphothreonine.
Protein Length
576 AA.
Protein Sequence
(Canonical)
MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ  60
PIGRLLFREF CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE  120
VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF LQWKWLERQP  180
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK  240
VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE  300
DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVKNE  360
RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVPEEYSE RFSPQARSLC  420
SQLLCKDPAE RLGCRGGSAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI  480
EQFSTVKGVE LEPTDQDFYQ KFATGSVPIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK  540
GQPPAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL                            576
FASTA
(Canonical)
>LipidDB-9606-00425|P43250
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ
PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE
VPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK
VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE
DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNE
RYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLC
SQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDI
EQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWK
GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
Gene Ontology
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0004703; F:G-protein coupled receptor kinase activity; IEA:UniProtKB-EC
GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro
GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW
Interpro
InterPro; IPR000961; AGC-kinase_C
InterPro; IPR000239; GPCR_kinase
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR016137; Regulat_G_prot_signal_superfam
InterPro; IPR000342; RGS_dom
InterPro; IPR002290; Ser/Thr_dual-sp_kinase
InterPro; IPR008271; Ser/Thr_kinase_AS
Pfam
Pfam; PF00069; Pkinase;
Pfam; PF00615; RGS;
SMART
SMART; SM00315; RGS;
SMART; SM00133; S_TK_X;
SMART; SM00220; S_TKc;
PROSITE
PROSITE; PS51285; AGC_KINASE_CTER;
PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;
PROSITE; PS00108; PROTEIN_KINASE_ST;
PROSITE; PS50132; RGS;
PRINTS
PRINTS; PR00717; GPCRKINASE;