| Tag |
Content |
LipidDB ID |
LipidDB-9606-00422 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.65 |
Molecular Weight |
493952.84 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Dynein heavy chain 1, axonemal |
Protein Synonyms/Alias |
Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; Heat shock regulated protein 1; HSRF-1; hDHC7; |
Gene Name |
DNAH1 |
Gene Synonyms/Alias |
DHC7; DNAHC1; KIAA1410; |
Created Date |
26-FEB-2008 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
369 | Canonical | LFCAEDPCMFAQRVV | [1] | S-Palmitoylation | 630 | Canonical | SQFISDTCCSVLNCT | [1] | S-Palmitoylation | 2225 | Canonical | TNKKPVLCIGPTGTG | [1] | S-Palmitoylation | 2736 | Canonical | QFPSLVNCCTIDWFN | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). |
Sequence Annotation |
Nucleotide-binding: 1581 1588 ATP.
Nucleotide-binding: 1862 1869 ATP.
Nucleotide-binding: 2227 2234 ATP.
Nucleotide-binding: 2586 2593 ATP.
Region: 1 1542 Stem.
Region: 1543 1764 AAA 1.
Region: 1824 2057 AAA 2.
Region: 2189 2449 AAA 3.
Region: 2547 2799 AAA 4.
Region: 2814 3112 Stalk.
Region: 3262 3492 AAA 5.
Region: 3705 3924 AAA 6.
Motif: 1581 1588 GPAGTGKT motif.
Motif: 1631 1637 CFDEFNR motif.
|
Protein Length |
4330 AA. |
Protein Sequence
(Canonical) |
MEQPNSKGYS LGRTPQGPEC SSAPAVQVGT HRGLEYNPGK ILPGSDYGLG NPPALDPKLP 60
HLPLPPAPPT LSDLGQPRKS PLTGTDKKYP LMKQRGFYSD ILSPGTLDQL GEVCRGPRMS 120
QNLLRQADLD KFTPRVGSFE VPEDFQERME QQCIGSTTRL LAQTDFPLQA YEPKMQVPFQ 180
VLPGQHPRKI EIERRKQQYL SLDIEQLLFS QGIDSNKLMP RHLDHQHPQT IEQGHDPIFP 240
IYLPLKVFDN EDFDCRTPRE WINMGLEPGS LDRKPVPGKA LLPTDDFLGH EDPKSQKLKY 300
KWCEVGVLDY DEEKKLYLVH KTDEKGLVRD EMGRPILNAG VTTEGRPPLQ VCQYWVPRIQ 360
LLFCAEDPCM FAQRVVQANA LRKNTEALLL YNLYVDCMPS DGQHVISEQS LSKIKQWALS 420
TPRMRKGPSV LEHLSSLARE VSLDYERSMN KINFDHVVSS KPETFSYVTL PKKEEEQVPE 480
RGLVSVPKYH FWEQKEDFTF VSLLTRPEVI TALSKVRAEC NKVTAMSLFH SSLSKYSHLE 540
EFEQIQSQTF SQVQMFLKDS WISSLKVAMR SSLRDMSKGW YNLYETNWEV YLMSKLRKLM 600
ELVKYMLQDT LRFLVQDSLA SFSQFISDTC CSVLNCTDDM VWGDDLINSP YRPRKNPLFI 660
MDLVLDSSGV HYSTPLEQFE ASLLNLFDKG ILATHAVPQL EKLVMEDIFI SGDPLLESVG 720
LHEPLVEELR ATIASAVSKA MIPLQAYAKE YRKYLELNNN DIASFLKTYQ TQGLLAQEVR 780
EVVLTHLREK EILDSSLPSS IIIGPFYINT DNVKQSLSKK RKALATSVLD ILAKNLHKEV 840
DSICEEFRSI SRKIYEKPNS IEELAELREW MKGIPERLVG LEERIVKVMD DYQVMDEFLY 900
NLSSDDFNDK WIASNWPSKI LGQIELVQQQ HVEDEEKFRK IQIMDQNNFQ EKLEGLQLVV 960
AGFSIHVEIS RAHEIANEVR RVKKQLKDCQ QLAMLYNNRE RIFSLPITNY DKLSRMVKEF 1020
QPYLDLWTTA SDWLRWSESW MNDPLSAIDA EQLEKNVVEA FKTMHKCVKQ FKDMPACQEV 1080
ALDIRARIEE FKPYIPLIQG LRNPGMRIRH WETLSNQINI NVRPKANLTF ARCLEMNLQD 1140
HIESISKVAE VAGKEYAIEQ ALDKMEKEWS TILFNVLPYK ATDTYILKSP DEASQLLDDH 1200
IVMTQNMSFS PYKKPFEQRI NSWENKLKLT QEVLEEWLNC QRSWLYLEPI FSSEDINQQL 1260
PVESKRYQTM ERIWKKIMKN AYENREVINV CSDLRMLDSL RDCNKILDLV QKGLSEYLET 1320
KRSAFPRFYF LSDDELLEIL SQTKDPTAVQ PHLRKCFENI ARLLFQEDLE ITHMYSAEGE 1380
EVQLCFSIYP SSNVEDWLRE VERSMKASVH DIIEKAIRAY PTMPRTQWVL NWPGQVTIAG 1440
CQTYWTMEVA EALEAGNLRS QLFPQLCQQL SDLVALVRGK LSRMQRAVLS ALIVIEVHAK 1500
DVVSKLIQEN VVSVNDFQWI SQLRYYWTNN DLYIRAVNAE FIYGYEYLGN SGRLVITPLT 1560
DRCYLTLTGA LHLKFGGAPA GPAGTGKTET TKDLGKALAI QTVVFNCSDQ LDFMAMGKFF 1620
KGLASAGAWA CFDEFNRIDI EVLSVVAQQI TTIQKAQQQR VERFMFEGVE IPLVPSCAVF 1680
ITMNPGYAGR TELPDNLKAL FRPVAMMVPD YAMITEISLY SFGFNEASVL AKKITTTFKL 1740
SSEQLSSQDH YDFGMRAVKT VISAAGNLKR ENPSMNEELI CLRAIRDVNV PKFLQEDLKL 1800
FSGIVSDLFP TIKEEDTDYG ILDEAIREAC RNSNLKDVEG FLTKCIQLYE TTVVRHGLML 1860
VGPTGSGKST CYRVLAAAMT SLKGQPSISG GMYEAVNYYV LNPKSITMGQ LYGEFDLLTH 1920
EWTDGIFSSF IRAGAITSDT NKKWYMFDGP VDAIWIENMN TVLDDNKKLC LSSGEIIKLT 1980
EAMTMMFEVQ DLAVASPATV SRCGMVYLEP SILGLMPFIE CWLRKLPPLL KPYEEHFKAL 2040
FVSFLEESIS FVRSSVKEVI ASTNCNLTMS LLKLLDCFFK PFLPREGLKK IPSEKLSRIV 2100
ELIEPWFIFS LIWSVGATGD SSGRTSFSHW LRLKMENEQL TLLFPEEGLV FDYRLEDAGI 2160
SGTNDSEDEE EEYKQVAWVK WMDSSAPFTM VPDTNYCNII VPTMDTVQMS HLLDMLLTNK 2220
KPVLCIGPTG TGKTLTISDK LLKNLALDYI SHFLTFSART SANQTQDFID SKLDKRRKGV 2280
FGPPLGRNFI FFIDDLNMPA LETYGAQPPI ELLRQWMDHG GWYDRKIIGA FKNLVDINFV 2340
CAMGPPGGGR NTVTPRLMRH FNYLSFAEMD EVSKKRIFST ILGNWLDGLL GEKSYRERVP 2400
GAPHIAHFTE PLVEATIMVY ATITSQLLPT PAKSHYTFNL RDLSKVFQGM LMADPAKVED 2460
QVQLLRLWYH ENCRVFRDRL VNEEDRSWFD QLLKRCMEQW EVTFNKVCPF QPILYGDFMS 2520
PGSDVKSYEL ITSESKMMQV IEEYIEDYNQ INTAKLKLVL FMDAMSHICR ISRTLRQALG 2580
NALLLGVGGS GRSSLTRLAS HMAEYECFQI ELSKNYGMSE WRDDVKKVLL KAGLQNLPIT 2640
FLFSDTQIKN ESFLEDINNV LNSGDIPNLY TADEQDQIVS TMRPYIQEQG LQPTKANLMA 2700
AYTGRVRSNI HMVLCMSPIG EVFRARLRQF PSLVNCCTID WFNEWPAEAL KSVATVFLNE 2760
IPELESSQEE IQGLIQVCVY IHQSVSKKCI EYLAELTRHN YVTPKSYLEL LHIFSILIGQ 2820
KKLELKTAKN RMKSGLDKLL RTSEDVAKMQ EDLESMHPLL EEAAKDTMLT MEQIKVDTAI 2880
AEETRNSVQT EEIKANEKAK KAQAIADDAQ KDLDEALPAL DAALASLRNL NKNDVTEVRA 2940
MQRPPPGVKL VIEAVCIMKG IKPKKVPGEK PGTKVDDYWE PGKGLLQDPG HFLESLFKFD 3000
KDNIGDVVIK AIQPYIDNEE FQPATIAKVS KACTSICQWV RAMHKYHFVA KAVEPKRQAL 3060
LEAQDDLGVT QRILDEAKQR LREVEDGIAT MQAKYRECIT KKEELELKCE QCEQRLGRAG 3120
KVRTLLLQGL QAGPAQTGAR KDQGAGGSWG GCPHPLPGNP GATVGRASPR PLAQPPRAHP 3180
TGLPLQLING LSDEKVRWQE TVENLQYMLN NISGDVLVAA GFVAYLGPFT GQYRTVLYDS 3240
WVKQLRSHNV PHTSEPTLIG TLGNPVKIRS WQIAGLPNDT LSVENGVINQ FSQRWTHFID 3300
PQSQANKWIK NMEKDNGLDV FKLSDRDFLR SMENAIRFGK PCLLENVGEE LDPALEPVLL 3360
KQTYKQQGNT VLKLGDTVIP YHEDFRMYIT TKLPNPHYTP EISTKLTLIN FTLSPSGLED 3420
QLLGQVVAEE RPDLEEAKNQ LIISNAKMRQ ELKDIEDQIL YRLSSSEGNP VDDMELIKVL 3480
EASKMKAAEI QAKVRIAEQT EKDIDLTRME YIPVAIRTQI LFFCVSDLAN VDPMYQYSLE 3540
WFLNIFLSGI ANSERADNLK KRISNINRYL TYSLYSNVCR SLFEKHKLMF AFLLCVRIMM 3600
NEGKINQSEW RYLLSGGSIS IMTENPAPDW LSDRAWRDIL ALSNLPTFSS FSSDFVKHLS 3660
EFRVIFDSLE PHREPLPGIW DQYLDQFQKL LVLRCLRGDK VTNAMQDFVA TNLEPRFIEP 3720
QTANLSVVFK DSNSTTPLIF VLSPGTDPAA DLYKFAEEMK FSKKLSAISL GQGQGPRAEA 3780
MMRSSIERGK WVFFQNCHLA PSWMPALERL IEHINPDKVH RDFRLWLTSL PSNKFPVSIL 3840
QNGSKMTIEP PRGVRANLLK SYSSLGEDFL NSCHKVMEFK SLLLSLCLFH GNALERHKFG 3900
PLGFNIPYEF TDGDLRICIS QLKMFLDEYD DIPYKVLKYT AGEINYGGRV TDDWDRRCIM 3960
NILEDFYNPD VLSPEHSYSA SGIYHQIPPT YDLHGYLSYI KSLPLNDMPE IFGLHDNANI 4020
TFAQNETFAL LGTIIQLQPK SSSAGSQGRE EIVEDVTQNI LLKVPEPINL QWVMAKYPVL 4080
YEESMNTVLV QEVIRYNRLL QVITQTLQDL LKALKGLVVM SSQLELMAAS LYNNTVPELW 4140
SAKAYPSLKP LSSWVMDLLQ RLDFLQAWIQ DGIPAVFWIS GFFFPQAFLT GTLQNFARKF 4200
VISIDTISFD FKVMFEAPSE LTQRPQVGCY IHGLFLEGAR WDPEAFQLAE SQPKELYTEM 4260
AVIWLLPTPN RKAQDQDFYL CPIYKTLTRA GTLSTTGHST NYVIAVEIPT HQPQRHWIKR 4320
GVALICALDY 4330
|
FASTA
(Canonical) |
>LipidDB-9606-00422|Q9P2D7
MEQPNSKGYSLGRTPQGPECSSAPAVQVGTHRGLEYNPGKILPGSDYGLGNPPALDPKLP
HLPLPPAPPTLSDLGQPRKSPLTGTDKKYPLMKQRGFYSDILSPGTLDQLGEVCRGPRMS
QNLLRQADLDKFTPRVGSFEVPEDFQERMEQQCIGSTTRLLAQTDFPLQAYEPKMQVPFQ
VLPGQHPRKIEIERRKQQYLSLDIEQLLFSQGIDSNKLMPRHLDHQHPQTIEQGHDPIFP
IYLPLKVFDNEDFDCRTPREWINMGLEPGSLDRKPVPGKALLPTDDFLGHEDPKSQKLKY
KWCEVGVLDYDEEKKLYLVHKTDEKGLVRDEMGRPILNAGVTTEGRPPLQVCQYWVPRIQ
LLFCAEDPCMFAQRVVQANALRKNTEALLLYNLYVDCMPSDGQHVISEQSLSKIKQWALS
TPRMRKGPSVLEHLSSLAREVSLDYERSMNKINFDHVVSSKPETFSYVTLPKKEEEQVPE
RGLVSVPKYHFWEQKEDFTFVSLLTRPEVITALSKVRAECNKVTAMSLFHSSLSKYSHLE
EFEQIQSQTFSQVQMFLKDSWISSLKVAMRSSLRDMSKGWYNLYETNWEVYLMSKLRKLM
ELVKYMLQDTLRFLVQDSLASFSQFISDTCCSVLNCTDDMVWGDDLINSPYRPRKNPLFI
MDLVLDSSGVHYSTPLEQFEASLLNLFDKGILATHAVPQLEKLVMEDIFISGDPLLESVG
LHEPLVEELRATIASAVSKAMIPLQAYAKEYRKYLELNNNDIASFLKTYQTQGLLAQEVR
EVVLTHLREKEILDSSLPSSIIIGPFYINTDNVKQSLSKKRKALATSVLDILAKNLHKEV
DSICEEFRSISRKIYEKPNSIEELAELREWMKGIPERLVGLEERIVKVMDDYQVMDEFLY
NLSSDDFNDKWIASNWPSKILGQIELVQQQHVEDEEKFRKIQIMDQNNFQEKLEGLQLVV
AGFSIHVEISRAHEIANEVRRVKKQLKDCQQLAMLYNNRERIFSLPITNYDKLSRMVKEF
QPYLDLWTTASDWLRWSESWMNDPLSAIDAEQLEKNVVEAFKTMHKCVKQFKDMPACQEV
ALDIRARIEEFKPYIPLIQGLRNPGMRIRHWETLSNQININVRPKANLTFARCLEMNLQD
HIESISKVAEVAGKEYAIEQALDKMEKEWSTILFNVLPYKATDTYILKSPDEASQLLDDH
IVMTQNMSFSPYKKPFEQRINSWENKLKLTQEVLEEWLNCQRSWLYLEPIFSSEDINQQL
PVESKRYQTMERIWKKIMKNAYENREVINVCSDLRMLDSLRDCNKILDLVQKGLSEYLET
KRSAFPRFYFLSDDELLEILSQTKDPTAVQPHLRKCFENIARLLFQEDLEITHMYSAEGE
EVQLCFSIYPSSNVEDWLREVERSMKASVHDIIEKAIRAYPTMPRTQWVLNWPGQVTIAG
CQTYWTMEVAEALEAGNLRSQLFPQLCQQLSDLVALVRGKLSRMQRAVLSALIVIEVHAK
DVVSKLIQENVVSVNDFQWISQLRYYWTNNDLYIRAVNAEFIYGYEYLGNSGRLVITPLT
DRCYLTLTGALHLKFGGAPAGPAGTGKTETTKDLGKALAIQTVVFNCSDQLDFMAMGKFF
KGLASAGAWACFDEFNRIDIEVLSVVAQQITTIQKAQQQRVERFMFEGVEIPLVPSCAVF
ITMNPGYAGRTELPDNLKALFRPVAMMVPDYAMITEISLYSFGFNEASVLAKKITTTFKL
SSEQLSSQDHYDFGMRAVKTVISAAGNLKRENPSMNEELICLRAIRDVNVPKFLQEDLKL
FSGIVSDLFPTIKEEDTDYGILDEAIREACRNSNLKDVEGFLTKCIQLYETTVVRHGLML
VGPTGSGKSTCYRVLAAAMTSLKGQPSISGGMYEAVNYYVLNPKSITMGQLYGEFDLLTH
EWTDGIFSSFIRAGAITSDTNKKWYMFDGPVDAIWIENMNTVLDDNKKLCLSSGEIIKLT
EAMTMMFEVQDLAVASPATVSRCGMVYLEPSILGLMPFIECWLRKLPPLLKPYEEHFKAL
FVSFLEESISFVRSSVKEVIASTNCNLTMSLLKLLDCFFKPFLPREGLKKIPSEKLSRIV
ELIEPWFIFSLIWSVGATGDSSGRTSFSHWLRLKMENEQLTLLFPEEGLVFDYRLEDAGI
SGTNDSEDEEEEYKQVAWVKWMDSSAPFTMVPDTNYCNIIVPTMDTVQMSHLLDMLLTNK
KPVLCIGPTGTGKTLTISDKLLKNLALDYISHFLTFSARTSANQTQDFIDSKLDKRRKGV
FGPPLGRNFIFFIDDLNMPALETYGAQPPIELLRQWMDHGGWYDRKIIGAFKNLVDINFV
CAMGPPGGGRNTVTPRLMRHFNYLSFAEMDEVSKKRIFSTILGNWLDGLLGEKSYRERVP
GAPHIAHFTEPLVEATIMVYATITSQLLPTPAKSHYTFNLRDLSKVFQGMLMADPAKVED
QVQLLRLWYHENCRVFRDRLVNEEDRSWFDQLLKRCMEQWEVTFNKVCPFQPILYGDFMS
PGSDVKSYELITSESKMMQVIEEYIEDYNQINTAKLKLVLFMDAMSHICRISRTLRQALG
NALLLGVGGSGRSSLTRLASHMAEYECFQIELSKNYGMSEWRDDVKKVLLKAGLQNLPIT
FLFSDTQIKNESFLEDINNVLNSGDIPNLYTADEQDQIVSTMRPYIQEQGLQPTKANLMA
AYTGRVRSNIHMVLCMSPIGEVFRARLRQFPSLVNCCTIDWFNEWPAEALKSVATVFLNE
IPELESSQEEIQGLIQVCVYIHQSVSKKCIEYLAELTRHNYVTPKSYLELLHIFSILIGQ
KKLELKTAKNRMKSGLDKLLRTSEDVAKMQEDLESMHPLLEEAAKDTMLTMEQIKVDTAI
AEETRNSVQTEEIKANEKAKKAQAIADDAQKDLDEALPALDAALASLRNLNKNDVTEVRA
MQRPPPGVKLVIEAVCIMKGIKPKKVPGEKPGTKVDDYWEPGKGLLQDPGHFLESLFKFD
KDNIGDVVIKAIQPYIDNEEFQPATIAKVSKACTSICQWVRAMHKYHFVAKAVEPKRQAL
LEAQDDLGVTQRILDEAKQRLREVEDGIATMQAKYRECITKKEELELKCEQCEQRLGRAG
KVRTLLLQGLQAGPAQTGARKDQGAGGSWGGCPHPLPGNPGATVGRASPRPLAQPPRAHP
TGLPLQLINGLSDEKVRWQETVENLQYMLNNISGDVLVAAGFVAYLGPFTGQYRTVLYDS
WVKQLRSHNVPHTSEPTLIGTLGNPVKIRSWQIAGLPNDTLSVENGVINQFSQRWTHFID
PQSQANKWIKNMEKDNGLDVFKLSDRDFLRSMENAIRFGKPCLLENVGEELDPALEPVLL
KQTYKQQGNTVLKLGDTVIPYHEDFRMYITTKLPNPHYTPEISTKLTLINFTLSPSGLED
QLLGQVVAEERPDLEEAKNQLIISNAKMRQELKDIEDQILYRLSSSEGNPVDDMELIKVL
EASKMKAAEIQAKVRIAEQTEKDIDLTRMEYIPVAIRTQILFFCVSDLANVDPMYQYSLE
WFLNIFLSGIANSERADNLKKRISNINRYLTYSLYSNVCRSLFEKHKLMFAFLLCVRIMM
NEGKINQSEWRYLLSGGSISIMTENPAPDWLSDRAWRDILALSNLPTFSSFSSDFVKHLS
EFRVIFDSLEPHREPLPGIWDQYLDQFQKLLVLRCLRGDKVTNAMQDFVATNLEPRFIEP
QTANLSVVFKDSNSTTPLIFVLSPGTDPAADLYKFAEEMKFSKKLSAISLGQGQGPRAEA
MMRSSIERGKWVFFQNCHLAPSWMPALERLIEHINPDKVHRDFRLWLTSLPSNKFPVSIL
QNGSKMTIEPPRGVRANLLKSYSSLGEDFLNSCHKVMEFKSLLLSLCLFHGNALERHKFG
PLGFNIPYEFTDGDLRICISQLKMFLDEYDDIPYKVLKYTAGEINYGGRVTDDWDRRCIM
NILEDFYNPDVLSPEHSYSASGIYHQIPPTYDLHGYLSYIKSLPLNDMPEIFGLHDNANI
TFAQNETFALLGTIIQLQPKSSSAGSQGREEIVEDVTQNILLKVPEPINLQWVMAKYPVL
YEESMNTVLVQEVIRYNRLLQVITQTLQDLLKALKGLVVMSSQLELMAASLYNNTVPELW
SAKAYPSLKPLSSWVMDLLQRLDFLQAWIQDGIPAVFWISGFFFPQAFLTGTLQNFARKF
VISIDTISFDFKVMFEAPSELTQRPQVGCYIHGLFLEGARWDPEAFQLAESQPKELYTEM
AVIWLLPTPNRKAQDQDFYLCPIYKTLTRAGTLSTTGHSTNYVIAVEIPTHQPQRHWIKR
GVALICALDY
|
Gene Ontology |
|
Interpro |
|
Pfam |
|
SMART |
|
PROSITE |
|
PRINTS |
|