Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00411
Entry Name
UniProt Accession
Theoretical PI
9.35
Molecular Weight
19534.84
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Protein tyrosine phosphatase type IVA 3
Protein Synonyms/Alias
3.1.3.48; PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3;
Gene Name
PTP4A3
Gene Synonyms/Alias
PRL3;
Created Date
05-JUL-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
170
Canonical
PHTHKTRCCVM****
[1]
S-Farnesylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Si X, Zeng Q, Ng CH, Hong W, Pallen CJ. Interaction of farnesylated PRL-2, aprotein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II. J Biol Chem. 2001 Aug 31;276(35):32875-82. Epub 2001 Jul 10.[PMID:11447212]
Functional Description
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Sequence Annotation
Domain: 82 148 Tyrosine-protein phosphatase.
Active site: 72 72 Proton donor.
Active site: 104 104 Phosphocysteine intermediate.
Binding site: 110 110 Substrate.
Modified residue: 170 170 Cysteine methyl ester.
Protein Length
173 AA.
Protein Sequence
(Canonical)
MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK  60
DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI  120
ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM         173
FASTA
(Canonical)
>LipidDB-9606-00411|O75365
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEK
DGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALI
ESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
Gene Ontology
GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004727; F:prenylated protein tyrosine phosphatase activity; TAS:ProtInc
GO:0035335; P:peptidyl-tyrosine dephosphorylation; TAS:GOC
Interpro
InterPro; IPR029021; Prot-tyrosine_phosphatase-like
InterPro; IPR000387; Tyr/Dual-sp_Pase
InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt
Pfam
Pfam; PF00102; Y_phosphatase;
SMART
PROSITE
PROSITE; PS50056; TYR_PHOSPHATASE_2;
PRINTS