[1] Kumano-Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S.Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands viacaveolae/raft-dependent endocytosis. Biochem Biophys Res Commun. 2013 May10;434(3):594-9. doi: 10.1016/j.bbrc.2013.03.120. Epub 2013 Apr 10.[PMID:23583401]
Functional Description
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria.