Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00399
Entry Name
UniProt Accession
Theoretical PI
8.33
Molecular Weight
57668.35
Genbank Protein ID
AAD34290.1; AAD34291.1; AAC50351.1; AAM12644.1; AAM12645.1; AAT52231.1; CAH71987.1; CAH71987.1; CAH71987.1; CAH71987.1; CAH71988.1; CAH71988.1; CAH71988.1; CAH71988.1; CAH71989.1; CAH71989.1; CAH71989.1; CAH71989.1; CAH71990.1; CAH71990.1; CAH71990.1; CAH71990.1; CAH73809.1; CAH73809.1; CAH73809.1; CAH73809.1; CAH73810.1; CAH73810.1; CAH73810.1; CAH73810.1; CAH73811.1; CAH73811.1; CAH73811.1; CAH73811.1; CAH73812.1; CAH73812.1; CAH73812.1; CAH73812.1; CAI15140.1; CAI15140.1; CAI15140.1; CAI15140.1; CAI15141.1; CAI15141.1; CAI15141.1; CAI15141.1; CAI15142.1; CAI15142.1; CAI15142.1; CAI15142.1; CAI15143.1; CAI15143.1; CAI15143.1; CAI15143.1; CAI16818.1; CAI16818.1; CAI16818.1; CAI16818.1; CAI16819.1; CAI16819.1; CAI16819.1; CAI16819.1; CAI16820.1; CAI16820.1; CAI16820.1; CAI16820.1; CAI16821.1; CAI16821.1; CAI16821.1; CAI16821.1; EAW70086.1; AAH22009.1;
Genbank Nucleotide ID
Protein Name
Regulator of G-protein signaling 7
Protein Synonyms/Alias
RGS7;
Gene Name
RGS7
Gene Synonyms/Alias
Created Date
01-OCT-1996
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
133
Canonical
TDYAVYLCKRTMQNK
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Takida S, Fischer CC, Wedegaertner PB. Palmitoylation and plasma membranetargeting of RGS7 are promoted by alpha o. Mol Pharmacol. 2005 Jan;67(1):132-9.Epub 2004 Oct 20.[PMID:15496508]
Functional Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).
Sequence Annotation
Domain: 37 112 DEP.
Domain: 255 316 G protein gamma.
Domain: 333 448 RGS.
Modified residue: 434 434 Phosphoserine.
Protein Length
495 AA.
Protein Sequence
(Canonical)
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS  60
DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC  120
WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK  180
RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH  240
SPTHTPTPET KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY LEYDPFLLPP  300
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL  360
RFWLAVEDLK KRPIKEVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE  420
DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KKKSGNSMDR RTSFEKFAQN VGRNIPIFPC  480
HKNCTPTLRA STNLL                                                   495
FASTA
(Canonical)
>LipidDB-9606-00399|P49802
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGS
DIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNC
WEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKK
RDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSH
SPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPP
DPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENL
RFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFE
DAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPC
HKNCTPTLRASTNLL
Gene Ontology
GO:0005737; C:cytoplasm; IBA:RefGenome
GO:0005829; C:cytosol; IEA:Ensembl
GO:0044292; C:dendrite terminus; IEA:Ensembl
GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro
GO:0005634; C:nucleus; IEA:Ensembl
GO:0005886; C:plasma membrane; IBA:RefGenome
GO:0031681; F:G-protein beta-subunit binding; IPI:UniProt
GO:0005096; F:GTPase activator activity; IBA:RefGenome
GO:0004871; F:signal transducer activity; IEA:InterPro
GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro
GO:0035556; P:intracellular signal transduction; IEA:InterPro
GO:0043547; P:positive regulation of GTPase activity; IBA:GOC
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro
Interpro
InterPro; IPR000591; DEP_dom
InterPro; IPR015898; G-protein_gamma-like_dom
InterPro; IPR024066; Regulat_G_prot_signal_dom1
InterPro; IPR016137; Regulat_G_prot_signal_superfam
InterPro; IPR000342; RGS_dom
InterPro; IPR011991; WHTH_DNA-bd_dom
Pfam
Pfam; PF00610; DEP;
Pfam; PF00631; G-gamma;
Pfam; PF00615; RGS;
SMART
SMART; SM00049; DEP;
SMART; SM00224; GGL;
SMART; SM00315; RGS;
PROSITE
PROSITE; PS50186; DEP;
PROSITE; PS50132; RGS;
PRINTS
PRINTS; PR01301; RGSPROTEIN;