LipidDB ID

LipidDB-9606-00383

Entry Name

UniProt Accession

Q9UNK0; O60712; Q53XT8;

Theoretical PI

4.91

Molecular Weight

26906.7

Genbank Protein ID

AAD20831.1; AAC36466.1; AAC95285.1; AAP35983.1; EAW90029.1; AAH09713.1;

Genbank Nucleotide ID

AF115323; AF062077; AF036715; BT007319; CH471108; BC009713;

Protein Name

Syntaxin-8

Protein Synonyms/Alias

Gene Name

STX8

Gene Synonyms/Alias

Created Date

01-DEC-2000

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] He Y, Linder ME. Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. J Lipid Res. 2009 Mar;50(3):398-404. doi:10.1194/jlr.M800360-JLR200. Epub 2008 Oct 31.[PMID:18980942]

Functional Description

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Sequence Annotation

Topological domain: 1 215 Cytoplasmic.
Transmembrane: 216 232 Helical; Anchor for type IV membraneprotein.
Topological domain: 233 236 Vesicular.
Domain: 145 207 t-SNARE coiled-coil homology.
Modified residue: 160 160 Phosphoserine.

Protein Length

236 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005783; C:endoplasmic reticulum; TAS:ProtInc
GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0031902; C:late endosome membrane; IEA:Ensembl
GO:0005765; C:lysosomal membrane; IEA:Ensembl
GO:0031201; C:SNARE complex; IBA:RefGenome
GO:0005484; F:SNAP receptor activity; IBA:RefGenome
GO:0008333; P:endosome to lysosome transport; IEA:Ensembl
GO:0006886; P:intracellular protein transport; IBA:RefGenome
GO:0006810; P:transport; TAS:ProtInc
GO:0006906; P:vesicle fusion; IBA:RefGenome

Interpro

InterPro; IPR000727; T_SNARE_dom

Pfam

Pfam; PF05739; SNARE;

SMART

SMART; SM00397; t_SNARE;

PROSITE

PROSITE; PS50192; T_SNARE;

PRINTS