LipidDB ID

LipidDB-9606-00379

Entry Name

UniProt Accession

O43561; B7WPI0; C7C5T6; G5E9K3; O43919;

Theoretical PI

4.27

Molecular Weight

27929.78

Genbank Protein ID

AAC39637.1; AAC39636.1; CAA11218.1; CBA11533.1; EAW52027.1; EAW52028.1; AAH11563.1;

Genbank Nucleotide ID

AF036906; AF036905; AJ223280; FN432832; AC109460; CH471267; CH471267; BC011563;

Protein Name

Linker for activation of T-cells family member 1

Protein Synonyms/Alias

36 kDa phospho-tyrosine adapter protein; pp36; p36-38;

Gene Name

LAT

Gene Synonyms/Alias

Created Date

01-JUN-2001

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Zhang W, Trible RP, Samelson LE. LAT palmitoylation: its essential role inmembrane microdomain targeting and tyrosine phosphorylation during T cellactivation. Immunity. 1998 Aug;9(2):239-46.[PMID:9729044]

Functional Description

Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Sequence Annotation

Topological domain: 1 4 Extracellular.
Transmembrane: 5 27 Helical; Signal-anchor for type IIImembrane protein.
Topological domain: 28 262 Cytoplasmic.
Region: 161 164 Interaction with PLCG1.
Region: 200 203 Interaction with GRB2, GRAP2 and PIK3R1.
Region: 220 223 Interaction with GRB2, GRAP2 and PIK3R1.
Modified residue: 39 39 Phosphothreonine.
Modified residue: 40 40 Phosphoserine.
Modified residue: 41 41 Phosphoserine.
Modified residue: 43 43 Phosphoserine.
Modified residue: 84 84 Phosphoserine.
Modified residue: 101 101 Phosphoserine.
Modified residue: 106 106 Phosphoserine.
Modified residue: 110 110 Phosphotyrosine.
Modified residue: 156 156 Phosphotyrosine.
Modified residue: 161 161 Phosphotyrosine.
Modified residue: 200 200 Phosphotyrosine.
Modified residue: 220 220 Phosphotyrosine.
Modified residue: 224 224 Phosphoserine.
Modified residue: 240 240 Phosphoserine.
Modified residue: 241 241 Phosphoserine.
Modified residue: 255 255 Phosphotyrosine.

Protein Length

262 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005911; C:cell-cell junction; IEA:Ensembl
GO:0008180; C:COP9 signalosome; ISS:UniProtKB
GO:0001772; C:immunological synapse; IDA:HGNC
GO:0016021; C:integral component of membrane; IDA:HGNC
GO:0042629; C:mast cell granule; IEA:GOC
GO:0045121; C:membrane raft; TAS:HGNC
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0019901; F:protein kinase binding; IPI:UniProtKB
GO:0005070; F:SH3/SH2 adaptor activity; IDA:HGNC
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0019722; P:calcium-mediated signaling; IMP:HGNC
GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome
GO:0010467; P:gene expression; IEA:Ensembl
GO:0006955; P:immune response; IDA:HGNC
GO:0006954; P:inflammatory response; IEA:Ensembl
GO:0045087; P:innate immune response; TAS:Reactome
GO:0007229; P:integrin-mediated signaling pathway; IDA:HGNC
GO:0035556; P:intracellular signal transduction; IDA:HGNC
GO:0002260; P:lymphocyte homeostasis; IEA:Ensembl
GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW
GO:0030168; P:platelet activation; TAS:Reactome
GO:0009967; P:positive regulation of signal transduction; IDA:GOC
GO:0007265; P:Ras protein signal transduction; IMP:HGNC
GO:0050863; P:regulation of T cell activation; IMP:HGNC
GO:0042110; P:T cell activation; TAS:UniProtKB
GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome

Interpro

InterPro; IPR008359; Linker_for_activat_Tcells_prot

Pfam

Pfam; PF15234; LAT;

SMART

PROSITE

PRINTS

PRINTS; PR01781; LATPROTEIN;