Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00378
Entry Name
UniProt Accession
Theoretical PI
5.46
Molecular Weight
63145.62
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Raftlin
Protein Synonyms/Alias
Cell migration-inducing gene 2 protein; Raft-linking protein;
Gene Name
RFTN1
Gene Synonyms/Alias
KIAA0084; MIG2;
Created Date
01-NOV-1997
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGCGLNKLE
[1][2]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Suzuki T, Moriya K, Nagatoshi K, Ota Y, Ezure T, Ando E, Tsunasawa S, UtsumiT. Strategy for comprehensive identification of human N-myristoylated proteinsusing an insect cell-free protein synthesis system. Proteomics. 2010May;10(9):1780-93. doi: 10.1002/pmic.200900783.[PMID:20213681]
[2] Saeki K, Miura Y, Aki D, Kurosaki T, Yoshimura A. The B cell-specific majorraft protein, Raftlin, is necessary for the integrity of lipid raft and BCRsignal transduction. EMBO J. 2003 Jun 16;22(12):3015-26.[PMID:12805216]
Functional Description
May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor- mediated signaling.
Sequence Annotation
Modified residue: 183 183 Phosphoserine.
Modified residue: 220 220 Phosphoserine.
Protein Length
578 AA.
Protein Sequence
(Canonical)
MGCGLNKLEK RDEKRPGNIY STLKRPQVET KIDVSYEYRF LEFTTLSAAE LPGSSAVRLA  60
SLRDLPAQLL ELYQQGFSLA ALHPFVQPTH EREKTPLEHI FRAILIKKTD RSQKTDLHNE  120
GYILELDCCS SLDHPTDQKL IPEFIKKIQE AASQGLKFVG VIPQYHSSVN SAGSSAPVST  180
ANSTEDARDA KNARGDHASL ENEKPGTGDV CSAPAGRNQS PEPSSGPRGE VPLAKQPSSP  240
SGEGDGGELS PQGVSKTLDG PESNPLEVHE EPLSGKMEIF TLFNKPKSHQ KCRQYYPVTI  300
PLHVSKNGQT VSGLDANWLE HMSDHFRKGG MLVNAVFYLG IVNDSLHGLT DGVFIFEAVS  360
TEDSKTIQGY DAIVVEQWTV LEGVEVQTDY VPLLNSLAAY GWQLTCVLPT PVVKTTSEGS  420
VSTKQIVFLQ RPCLPQKIKK KESKFQWRFS REEMHNRQMR KSKGKLSARD KQQAEENEKN  480
LEDQSSKAGD MGNCVSGQQQ EGGVSEEMKG PVQEDKGEQL SPGGLLCGVG VEGEAVQNGP  540
ASHSRALVGI CTGHSNPGED ARDGDAEEVR ELGTVEEN                          578
FASTA
(Canonical)
>LipidDB-9606-00378|Q14699
MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLA
SLRDLPAQLLELYQQGFSLAALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNE
GYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVGVIPQYHSSVNSAGSSAPVST
ANSTEDARDAKNARGDHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQPSSP
SGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGKMEIFTLFNKPKSHQKCRQYYPVTI
PLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVS
TEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVVKTTSEGS
VSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKSKGKLSARDKQQAEENEKN
LEDQSSKAGDMGNCVSGQQQEGGVSEEMKGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGP
ASHSRALVGICTGHSNPGEDARDGDAEEVRELGTVEEN
Gene Ontology
GO:0005737; C:cytoplasm; IDA:MGI
GO:0005768; C:endosome; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0045121; C:membrane raft; IDA:UniProt
GO:0005886; C:plasma membrane; IDA:UniProt
GO:0043234; C:protein complex; IDA:MGI
GO:0003725; F:double-stranded RNA binding; IDA:MGI
GO:0050853; P:B cell receptor signaling pathway; IMP:UniProt
GO:0033227; P:dsRNA transport; IMP:MGI
GO:0040007; P:growth; IMP:UniProt
GO:0032620; P:interleukin-17 production; ISS:UniProt
GO:0001765; P:membrane raft assembly; IMP:UniProt
GO:1903044; P:protein localization to membrane raft; ISS:UniProt
GO:0032596; P:protein transport into membrane raft; ISS:UniProt
GO:0043330; P:response to exogenous dsRNA; IMP:MGI
GO:0002457; P:T cell antigen processing and presentation; ISS:UniProt
GO:0050852; P:T cell receptor signaling pathway; ISS:UniProt
GO:0034138; P:toll-like receptor 3 signaling pathway; IMP:MGI
Interpro
InterPro; IPR028169; Raftlin
Pfam
Pfam; PF15250; Raftlin;
SMART
PROSITE
PRINTS