LipidDB ID

LipidDB-9606-00370

Entry Name

UniProt Accession

Q9H0U4; A8K7S1;

Theoretical PI

5.55

Molecular Weight

22171.16

Genbank Protein ID

AAP97212.1; CAB66570.1; BAF84775.1; BAG37733.1; AAH71169.1;

Genbank Nucleotide ID

AF092437; AL136635; AK292086; AK315333; BC071169;

Protein Name

Ras-related protein Rab-1B

Protein Synonyms/Alias

Gene Name

RAB1B

Gene Synonyms/Alias

Created Date

19-SEP-2002

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Overmeyer JH, Wilson AL, Maltese WA. Membrane targeting of a Rab GTPase thatfails to associate with Rab escort protein (REP) or guanine nucleotidedissociation inhibitor (GDI). J Biol Chem. 2001 Jun 8;276(23):20379-86. Epub 2001Mar 16.[PMID:11389151]
[2] Wilson AL, Sheridan KM, Erdman RA, Maltese WA. Prenylation of a Rab1B mutantwith altered GTPase activity is impaired in cell-free systems but not in intactmammalian cells. Biochem J. 1996 Sep 15;318 ( Pt 3):1007-14.[PMID:8836150]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.

Sequence Annotation

Nucleotide-binding: 15 22 GTP.
Nucleotide-binding: 63 67 GTP.
Nucleotide-binding: 121 124 GTP.
Region: 64 83 Switch 2 region; required for interactionwith REP1/CHM.
Motif: 37 45 Effector region.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 76 76 O-(2-cholinephosphoryl)serine; byLegionella AnkX.
Modified residue: 77 77 O-AMP-tyrosine; by Legionella DrrA.
Modified residue: 201 201 Cysteine methyl ester.

Protein Length

201 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:LIFEdb
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0006888; P:ER to Golgi vesicle-mediated transport; IGI:UniProtKB
GO:1903020; P:positive regulation of glycoprotein metabolic process; IGI:UniProtKB
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0019068; P:virion assembly; IGI:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;