LipidDB ID

LipidDB-9606-00361

Entry Name

UniProt Accession

P10114; B2RCJ1; Q5JSC1; Q5JSC2;

Theoretical PI

4.73

Molecular Weight

20615.46

Genbank Protein ID

CAA31052.1; AAN71845.1; AAM12628.1; BAG37588.1; CAI39499.1; EAX08974.1; AAH41333.1; AAH70031.1;

Genbank Nucleotide ID

X12534; AF205602; AF493914; AK315139; AL442067; CH471085; BC041333; BC070031;

Protein Name

Ras-related protein Rap-2a

Protein Synonyms/Alias

RbBP-30;

Gene Name

RAP2A

Gene Synonyms/Alias

Created Date

01-JUL-1989

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid
[2] Farrell FX, Yamamoto K, Lapetina EG. Prenyl group identification of rap2proteins: a ras superfamily member other than ras that is farnesylated. BiochemJ. 1993 Jan 15;289 ( Pt 2):349-55.[PMID:8424780]

Functional Description

Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Motif: 32 40 Effector region.
Modified residue: 180 180 Cysteine methyl ester.

Protein Length

183 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005829; C:cytosol; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0055037; C:recycling endosome; IDA:MGI
GO:0055038; C:recycling endosome membrane; IDA:UniProtKB
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB
GO:0034613; P:cellular protein localization; IDA:UniProtKB
GO:0045184; P:establishment of protein localization; IDA:MGI
GO:0030336; P:negative regulation of cell migration; IEA:Ensembl
GO:0031954; P:positive regulation of protein autophosphorylation; IDA:UniProtKB
GO:0032486; P:Rap protein signal transduction; ISS:UniProtKB
GO:0048814; P:regulation of dendrite morphogenesis; IDA:UniProtKB
GO:0046328; P:regulation of JNK cascade; IDA:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;