LipidDB ID

LipidDB-9606-00354

Entry Name

UniProt Accession

P40855; D3DVE7; Q5QNY4; Q8NI97;

Theoretical PI

4.26

Molecular Weight

32806.5

Genbank Protein ID

CAA53225.1; CAA70257.1; BAA76291.1; BAB93469.1; AAP35525.1; CAI12457.1; EAW52728.1; EAW52729.1; AAH00496.1;

Genbank Nucleotide ID

X75535; Y09048; AB018541; AB062286; BT006879; AL513282; CH471121; CH471121; BC000496;

Protein Name

Peroxisomal biogenesis factor 19

Protein Synonyms/Alias

33 kDa housekeeping protein; Peroxin-19; Peroxisomal farnesylated protein;

Gene Name

PEX19

Gene Synonyms/Alias

HK33; PXF; OK/SW-cl.22;

Created Date

01-FEB-1995

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, WandersRJ, Suzuki Y, Kondo N, Fujiki Y. Human PEX19: cDNA cloning by functionalcomplementation, mutation analysis in a patient with Zellweger syndrome, andpotential role in peroxisomal membrane assembly. Proc Natl Acad Sci U S A. 1999Mar 2;96(5):2116-21.[PMID:10051604]
[2] Kammerer S, Arnold N, Gutensohn W, Mewes HW, Kunau WH, Höfler G, Roscher AA,Braun A. Genomic organization and molecular characterization of a gene encodingHsPXF, a human peroxisomal farnesylated protein. Genomics. 1997 Oct1;45(1):200-10.[PMID:9339377]

Functional Description

Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.

Sequence Annotation

Region: 2 91 Necessary for PEX19 function onperoxisome biogenesis.
Region: 2 56 Docking to the peroxisome membrane andbinding to PEX3.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 35 35 Phosphoserine.
Modified residue: 296 296 Cysteine methyl ester.

Protein Length

299 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0031526; C:brush border membrane; ISS:UniProtKB
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005829; C:cytosol; IDA:UniProtKB
GO:0016021; C:integral component of membrane; IDA:UniProtKB
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA
GO:0005634; C:nucleus; IDA:HPA
GO:0005778; C:peroxisomal membrane; IDA:UniProtKB
GO:0005777; C:peroxisome; IDA:UniProtKB
GO:0043234; C:protein complex; IDA:UniProtKB
GO:0051117; F:ATPase binding; IPI:UniProtKB
GO:0036105; F:peroxisome membrane class-1 targeting sequence binding; IDA:UniProtKB
GO:0047485; F:protein N-terminus binding; IPI:UniProtKB
GO:0061077; P:chaperone-mediated protein folding; IDA:UniProtKB
GO:0072321; P:chaperone-mediated protein transport; IDA:UniProtKB
GO:0072663; P:establishment of protein localization to peroxisome; IMP:UniProtKB
GO:1900131; P:negative regulation of lipid binding; IDA:UniProtKB
GO:0016559; P:peroxisome fission; IMP:UniProtKB
GO:0016557; P:peroxisome membrane biogenesis; IDA:UniProtKB
GO:0007031; P:peroxisome organization; IMP:UniProtKB
GO:0045046; P:protein import into peroxisome membrane; IDA:UniProtKB
GO:0050821; P:protein stabilization; IDA:UniProtKB
GO:0006625; P:protein targeting to peroxisome; IDA:UniProtKB
GO:0055085; P:transmembrane transport; TAS:Reactome

Interpro

InterPro; IPR006708; Pex19

Pfam

Pfam; PF04614; Pex19;

SMART

PROSITE

PRINTS