Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00353
Entry Name
UniProt Accession
Theoretical PI
8.71
Molecular Weight
30077.17
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Myelin proteolipid protein
Protein Synonyms/Alias
PLP; Lipophilin;
Gene Name
PLP1
Gene Synonyms/Alias
PLP;
Created Date
01-JAN-1988
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
6
Canonical
**MGLLECCARCLVG
[1]
S-Palmitoylation
7
Canonical
*MGLLECCARCLVGA
[1]
S-Palmitoylation
10
Canonical
LLECCARCLVGAPFA
[1]
S-Palmitoylation
109
Canonical
GDYKTTICGKGLSAT
[1]
S-Palmitoylation
139
Canonical
AHSLERVCHCLGKWL
[1]
S-Palmitoylation
141
Canonical
SLERVCHCLGKWLGH
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Schneider A, Länder H, Schulz G, Wolburg H, Nave KA, Schulz JB, Simons M.Palmitoylation is a sorting determinant for transport to the myelin membrane. JCell Sci. 2005 Jun 1;118(Pt 11):2415-23.[PMID:15923654]
Functional Description
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Sequence Annotation
Topological domain: 2 9 Cytoplasmic.
Transmembrane: 10 36 Helical; Name=1.
Topological domain: 37 63 Extracellular.
Transmembrane: 64 88 Helical; Name=2.
Topological domain: 89 151 Cytoplasmic.
Transmembrane: 152 177 Helical; Name=3.
Topological domain: 178 233 Extracellular.
Transmembrane: 234 260 Helical; Name=4.
Topological domain: 261 277 Cytoplasmic.
Protein Length
277 AA.
Protein Sequence
(Canonical)
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY FSKNYQDYEY  60
LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI FGDYKTTICG KGLSATVTGG  120
QKGRGSRGQH QAHSLERVCH CLGKWLGHPD KFVGITYALT VVWLLVFACS AVPVYIYFNT  180
WTTCQSIAFP SKTSASIGSL CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF  240
IAAFVGAAAT LVSLLTFMIA ATYNFAVLKL MGRGTKF                           277
FASTA
(Canonical)
>LipidDB-9606-00353|P60201
MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEY
LINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGG
QKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNT
WTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLF
IAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0043209; C:myelin sheath; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0019911; F:structural constituent of myelin sheath; IEA:Ensembl
GO:0005198; F:structural molecule activity; TAS:ProtInc
GO:0014002; P:astrocyte development; IEA:Ensembl
GO:0061564; P:axon development; IEA:Ensembl
GO:0008366; P:axon ensheathment; TAS:ProtInc
GO:0008219; P:cell death; IEA:UniProtKB-KW
GO:0048469; P:cell maturation; IEA:Ensembl
GO:0022010; P:central nervous system myelination; IEA:Ensembl
GO:0006954; P:inflammatory response; IEA:Ensembl
GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl
GO:0042759; P:long-chain fatty acid biosynthetic process; IEA:Ensembl
GO:0010628; P:positive regulation of gene expression; IEA:Ensembl
GO:0021762; P:substantia nigra development; IEP:UniProt
GO:0007268; P:synaptic transmission; TAS:ProtInc
Interpro
InterPro; IPR001614; Myelin_PLP
InterPro; IPR018237; Myelin_PLP_CS
Pfam
Pfam; PF01275; Myelin_PLP;
SMART
SMART; SM00002; PLP;
PROSITE
PROSITE; PS00575; MYELIN_PLP_1;
PROSITE; PS01004; MYELIN_PLP_2;
PRINTS
PRINTS; PR00214; MYELINPLP;