LipidDB ID

LipidDB-9606-00351

Entry Name

UniProt Accession

P40616; B4DWW1; P80417; Q53XB1;

Theoretical PI

5.63

Molecular Weight

20417.53

Genbank Protein ID

AAC37567.1; AAM12601.1; AAP35924.1; BAG63173.1; BAG34736.1; CAD97629.1; EAW97658.1; AAH07000.1;

Genbank Nucleotide ID

L28997; AF493887; BT007260; AK301701; AK311793; BX537387; AC063948; CH471054; BC007000;

Protein Name

ADP-ribosylation factor-like protein 1

Protein Synonyms/Alias

Gene Name

ARL1

Gene Synonyms/Alias

Created Date

01-FEB-1995

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, MassenburgD, Moss J, Lee FJ. ARL4, an ARF-like protein that is developmentally regulatedand localized to nuclei and nucleoli. J Biol Chem. 2000 Dec 1;275(48):37815-23.[PMID:10980193]

Functional Description

GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.

Sequence Annotation

Nucleotide-binding: 24 31 GTP.
Nucleotide-binding: 45 48 GTP.
Nucleotide-binding: 67 71 GTP.
Nucleotide-binding: 126 129 GTP.
Nucleotide-binding: 160 161 GTP.
Metal binding site: 31 31 Magnesium.
Metal binding site: 48 48 Magnesium.
Binding site: 70 70 GTP; via amide nitrogen.

Protein Length

181 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0005794; C:Golgi apparatus; IDA:UniProtKB
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0005802; C:trans-Golgi network; ISS:UniProtKB
GO:0008047; F:enzyme activator activity; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0019904; F:protein domain specific binding; IPI:UniProtKB
GO:0031584; P:activation of phospholipase D activity; IDA:UniProtKB
GO:0007030; P:Golgi organization; ISS:UniProtKB
GO:0048193; P:Golgi vesicle transport; IEA:Ensembl
GO:0006184; P:GTP catabolic process; IDA:UniProtKB
GO:0034067; P:protein localization to Golgi apparatus; IMP:UniProtKB
GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
GO:0009404; P:toxin metabolic process; IDA:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR024156; Small_GTPase_ARF
InterPro; IPR006689; Small_GTPase_ARF/SAR

Pfam

Pfam; PF00025; Arf;

SMART

SMART; SM00177; ARF;

PROSITE

PROSITE; PS51417; ARF;

PRINTS

PRINTS; PR00328; SAR1GTPBP;