Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00341
Entry Name
UniProt Accession
Theoretical PI
9.26
Molecular Weight
22615.22
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
ADP-ribosylation factor-like protein 4A
Protein Synonyms/Alias
Gene Name
ARL4A
Gene Synonyms/Alias
ARL4;
Created Date
01-FEB-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGNGLSDQT
[1]
N-Myristoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, MassenburgD, Moss J, Lee FJ. ARL4, an ARF-like protein that is developmentally regulatedand localized to nuclei and nucleoli. J Biol Chem. 2000 Dec 1;275(48):37815-23.[PMID:10980193]
Functional Description
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.
Sequence Annotation
Nucleotide-binding: 27 34 GTP.
Nucleotide-binding: 75 79 GTP.
Nucleotide-binding: 134 137 GTP.
Protein Length
200 AA.
Protein Sequence
(Canonical)
MGNGLSDQTS ILSNLPSFQS FHIVILGLDC AGKTTVLYRL QFNEFVNTVP TKGFNTEKIK  60
VTLGNSKTVT FHFWDVGGQE KLRPLWKSYT RCTDGIVFVV DSVDVERMEE AKTELHKITR  120
ISENQGVPVL IVANKQDLRN SLSLSEIEKL LAMGELSSST PWHLQPTCAI IGDGLKEGLE  180
KLHDMIIKRR KMLRQQKKKR                                              200
FASTA
(Canonical)
>LipidDB-9606-00341|P40617
MGNGLSDQTSILSNLPSFQSFHIVILGLDCAGKTTVLYRLQFNEFVNTVPTKGFNTEKIK
VTLGNSKTVTFHFWDVGGQEKLRPLWKSYTRCTDGIVFVVDSVDVERMEEAKTELHKITR
ISENQGVPVLIVANKQDLRNSLSLSEIEKLLAMGELSSSTPWHLQPTCAIIGDGLKEGLE
KLHDMIIKRRKMLRQQKKKR
Gene Ontology
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0005730; C:nucleolus; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0050873; P:brown fat cell differentiation; IEA:Ensembl
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR024156; Small_GTPase_ARF
InterPro; IPR006689; Small_GTPase_ARF/SAR
Pfam
Pfam; PF00025; Arf;
SMART
SMART; SM00177; ARF;
PROSITE
PROSITE; PS51417; ARF;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;