LipidDB ID

LipidDB-9606-00322

Entry Name

UniProt Accession

Q9BRT3;

Theoretical PI

4.4

Molecular Weight

12402.96

Genbank Protein ID

AAR92035.1; AAO85461.1; AAH06006.1;

Genbank Nucleotide ID

AY508814; AF490253; AC079199; BC006006;

Protein Name

Migration and invasion enhancer 1

Protein Synonyms/Alias

HBV X-transactivated gene 4 protein; HBV XAg-transactivated protein 4; Protein C35;

Gene Name

MIEN1

Gene Synonyms/Alias

C17orf37; RDX12; XTP4;

Created Date

12-DEC-2006

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Evans EE, Henn AD, Jonason A, Paris MJ, Schiffhauer LM, Borrello MA, Smith ES,Sahasrabudhe DM, Zauderer M. C35 (C17orf37) is a novel tumor biomarker abundantlyexpressed in breast cancer. Mol Cancer Ther. 2006 Nov;5(11):2919-30.[PMID:17121940]
[2] Dasgupta S, Cushman I, Kpetemey M, Casey PJ, Vishwanatha JK. Prenylatedc17orf37 induces filopodia formation to promote cell migration and metastasis. J Biol Chem. 2011 Jul 22;286(29):25935-46. doi: 10.1074/jbc.M111.254599. Epub 2011 May 31.[PMID:21628459]
[3] Dasgupta S, Wasson LM, Rauniyar N, Prokai L, Borejdo J, Vishwanatha JK. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostatecancer cells. Oncogene. 2009 Aug 13;28(32):2860-72. doi: 10.1038/onc.2009.145.Epub 2009 Jun 8.[PMID:19503095]

Functional Description

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Sequence Annotation

Modified residue: 2 2 N-acetylserine.

Protein Length

115 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005829; C:cytosol; IDA:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0031235; C:intrinsic component of the cytoplasmic side of the plasma membrane; IDA:UniProtKB
GO:0008430; F:selenium binding; IEA:InterPro
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW
GO:0045454; P:cell redox homeostasis; IEA:InterPro
GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB
GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB
GO:0051491; P:positive regulation of filopodium assembly; IDA:UniProtKB

Interpro

InterPro; IPR011893; Selenoprotein_Rdx-typ
InterPro; IPR012336; Thioredoxin-like_fold

Pfam

Pfam; PF10262; Rdx;

SMART

PROSITE

PRINTS