LipidDB-9606-00320

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00320

Entry Name

CTR1_HUMAN

UniProt Accession

P30825; Q5JR50;

Theoretical PI

5.29

Molecular Weight

67638.37

Genbank Protein ID

CAA41869.1; CAA40560.1; AAC27721.1; CAI39913.1; AAH63303.1; AAH69358.1; AAI15408.1;

Genbank Nucleotide ID

X59155; X57303; AF078107; AL596114; BC063303; BC069358; BC115407;

Protein Name

High affinity cationic amino acid transporter 1

Protein Synonyms/Alias

CAT-1; CAT1; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; ERR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter;

Gene Name

SLC7A1

Gene Synonyms/Alias

ATRC1; ERR; REC1L;

Created Date

01-OCT-1996

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
3	Canonical	*****MGCKVLLNIG	[1]	S-Palmitoylation
628	Canonical	PDGNLDQCK******	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.

Sequence Annotation

Topological domain: 1 35 Cytoplasmic.
Transmembrane: 36 57 Helical.
Topological domain: 58 61 Extracellular.
Transmembrane: 62 82 Helical.
Topological domain: 83 102 Cytoplasmic.
Transmembrane: 103 123 Helical.
Topological domain: 124 162 Extracellular.
Transmembrane: 163 183 Helical.
Topological domain: 184 191 Cytoplasmic.
Transmembrane: 192 212 Helical.
Topological domain: 213 246 Extracellular.
Transmembrane: 247 267 Helical.
Topological domain: 268 287 Cytoplasmic.
Transmembrane: 288 307 Helical.
Topological domain: 308 337 Extracellular.
Transmembrane: 338 358 Helical.
Topological domain: 359 384 Cytoplasmic.
Transmembrane: 385 405 Helical.
Topological domain: 406 408 Extracellular.
Transmembrane: 409 429 Helical.
Topological domain: 430 492 Cytoplasmic.
Transmembrane: 493 513 Helical.
Topological domain: 514 526 Extracellular.
Transmembrane: 527 551 Helical.
Topological domain: 552 559 Cytoplasmic.
Transmembrane: 560 580 Helical.
Topological domain: 581 584 Extracellular.
Transmembrane: 585 605 Helical.
Topological domain: 606 629 Cytoplasmic.

Protein Length

629 AA.

Protein Sequence
(Canonical)

MGCKVLLNIG QQMLRRKVVD CSREETRLSR CLNTFDLVAL GVGSTLGAGV YVLAGAVARE  60
NAGPAIVISF LIAALASVLA GLCYGEFGAR VPKTGSAYLY SYVTVGELWA FITGWNLILS  120
YIIGTSSVAR AWSATFDELI GRPIGEFSRT HMTLNAPGVL AENPDIFAVI IILILTGLLT  180
LGVKESAMVN KIFTCINVLV LGFIMVSGFV KGSVKNWQLT EEDFGNTSGR LCLNNDTKEG  240
KPGVGGFMPF GFSGVLSGAA TCFYAFVGFD CIATTGEEVK NPQKAIPVGI VASLLICFIA  300
YFGVSAALTL MMPYFCLDNN SPLPDAFKHV GWEGAKYAVA VGSLCALSAS LLGSMFPMPR  360
VIYAMAEDGL LFKFLANVND RTKTPIIATL ASGAVAAVMA FLFDLKDLVD LMSIGTLLAY  420
SLVAACVLVL RYQPEQPNLV YQMASTSDEL DPADQNELAS TNDSQLGFLP EAEMFSLKTI  480
LSPKNMEPSK ISGLIVNIST SLIAVLIITF CIVTVLGREA LTKGALWAVF LLAGSALLCA  540
VVTGVIWRQP ESKTKLSFKV PFLPVLPILS IFVNVYLMMQ LDQGTWVRFA VWMLIGFIIY  600
FGYGLWHSEE ASLDADQART PDGNLDQCK                                    629

FASTA
(Canonical)

>LipidDB-9606-00320|P30825
MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE
NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS
YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT
LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG
KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA
YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR
VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY
SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI
LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA
VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY
FGYGLWHSEEASLDADQARTPDGNLDQCK

Gene Ontology

GO:0005887; C:integral component of plasma membrane; TAS:ProtInc
GO:0016020; C:membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0015181; F:arginine transmembrane transporter activity; IEA:Ensembl
GO:0006865; P:amino acid transport; TAS:Reactome
GO:0006811; P:ion transport; TAS:Reactome
GO:0055085; P:transmembrane transport; TAS:Reactome
GO:0006810; P:transport; NAS:ProtInc

Interpro

InterPro; IPR002293; AA/rel_permease1
InterPro; IPR004755; Cat_AA_permease
InterPro; IPR029485; CAT_C

Pfam

Pfam; PF13520; AA_permease_2;
Pfam; PF13906; AA_permease_C;

SMART

PROSITE

PRINTS