LipidDB ID

LipidDB-9606-00313

Entry Name

UniProt Accession

Q15078; E1P664; Q5U0G3;

Theoretical PI

9.44

Molecular Weight

34060.18

Genbank Protein ID

CAA56587.1; AAQ74776.1; AAV38380.1; EAW80227.1; EAW80228.1; AAH20580.1;

Genbank Nucleotide ID

X80343; AY376350; BT019573; CH471147; CH471147; BC020580;

Protein Name

Cyclin-dependent kinase 5 activator 1, p25

Protein Synonyms/Alias

CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; p35; p25; Tau protein kinase II 23 kDa subunit; p23;

Gene Name

CDK5R1

Gene Synonyms/Alias

CDK5R; NCK5A;

Created Date

01-NOV-1997

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Suzuki T, Moriya K, Nagatoshi K, Ota Y, Ezure T, Ando E, Tsunasawa S, UtsumiT. Strategy for comprehensive identification of human N-myristoylated proteinsusing an insect cell-free protein synthesis system. Proteomics. 2010May;10(9):1780-93. doi: 10.1002/pmic.200900783.[PMID:20213681]
[2] Asada A, Yamamoto N, Gohda M, Saito T, Hayashi N, Hisanaga S. Myristoylationof p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes. J Neurochem. 2008 Aug;106(3):1325-36. doi:10.1111/j.1471-4159.2008.05500.x. Epub 2008 May 26.[PMID:18507738]

Functional Description

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Sequence Annotation

Functional site: 98 99 Cleavage; by calpain.
Modified residue: 8 8 Phosphoserine; by CDK5.
Modified residue: 138 138 Phosphothreonine; by CDK5.

Protein Length

307 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030424; C:axon; ISS:UniProtKB
GO:0043292; C:contractile fiber; ISS:UniProtKB
GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IEA:InterPro
GO:0005737; C:cytoplasm; ISS:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0030425; C:dendrite; ISS:UniProtKB
GO:0043197; C:dendritic spine; ISS:UniProtKB
GO:0030426; C:growth cone; ISS:UniProtKB
GO:0016020; C:membrane; ISS:UniProtKB
GO:0031594; C:neuromuscular junction; ISS:UniProtKB
GO:0043025; C:neuronal cell body; ISS:UniProtKB
GO:0005634; C:nucleus; ISS:UniProtKB
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0014069; C:postsynaptic density; ISS:UniProtKB
GO:0045296; F:cadherin binding; ISS:UniProtKB
GO:0005509; F:calcium ion binding; ISS:UniProtKB
GO:0016534; F:cyclin-dependent protein kinase 5 activator activity; IEA:Ensembl
GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl
GO:0016301; F:kinase activity; ISS:UniProtKB
GO:0004672; F:protein kinase activity; TAS:ProtInc
GO:0019901; F:protein kinase binding; IPI:UniProtKB
GO:0043539; F:protein serine/threonine kinase activator activity; IDA:UniProtKB
GO:0007411; P:axon guidance; ISS:UniProtKB
GO:0007413; P:axonal fasciculation; ISS:UniProtKB
GO:0007420; P:brain development; ISS:UniProtKB
GO:0008283; P:cell proliferation; TAS:ProtInc
GO:0021549; P:cerebellum development; IEA:Ensembl
GO:0009790; P:embryo development; IEA:Ensembl
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB
GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; ISS:UniProtKB
GO:0021766; P:hippocampus development; IEA:Ensembl
GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB
GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl
GO:0030517; P:negative regulation of axon extension; IEA:Ensembl
GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:DFLAT
GO:0007158; P:neuron cell-cell adhesion; ISS:UniProtKB
GO:0030182; P:neuron differentiation; ISS:UniProtKB
GO:0001764; P:neuron migration; ISS:UniProtKB
GO:0031175; P:neuron projection development; ISS:UniProtKB
GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB
GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB
GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB
GO:0090314; P:positive regulation of protein targeting to membrane; IEA:Ensembl
GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl
GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc
GO:0061001; P:regulation of dendritic spine morphogenesis; ISS:UniProtKB
GO:0070507; P:regulation of microtubule cytoskeleton organization; IEA:Ensembl
GO:0045664; P:regulation of neuron differentiation; NAS:UniProtKB
GO:0048511; P:rhythmic process; IEA:UniProtKB-KW
GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl
GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl

Interpro

InterPro; IPR004944; CDK5_activator
InterPro; IPR013763; Cyclin-like

Pfam

Pfam; PF03261; CDK5_activator;

SMART

PROSITE

PRINTS