LipidDB-9606-00293

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-9606-00293

Entry Name

AL1B1_HUMAN

UniProt Accession

P30837; B2R8F0; Q8WX76; Q9BV45;

Theoretical PI

6.36

Molecular Weight

57206.31

Genbank Protein ID

AAA96830.1; AAP36086.1; BAG36147.1; CAD13246.1; AAH01619.1;

Genbank Nucleotide ID

M63967; BT007418; AK313344; AL135785; BC001619;

Protein Name

Aldehyde dehydrogenase X, mitochondrial

Protein Synonyms/Alias

1.2.1.3; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1;

Gene Name

ALDH1B1

Gene Synonyms/Alias

ALDH5; ALDHX;

Created Date

01-JUL-1993

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
319	Canonical	FFNMGQCCCAGSRTF	[1]	S-Palmitoylation

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.

Sequence Annotation

Nucleotide-binding: 262 267 NAD.
Active site: 285 285 Proton acceptor.
Active site: 319 319 Nucleophile.
Functional site: 186 186 Transition state stabilizer.
Modified residue: 51 51 N6-acetyllysine.
Modified residue: 52 52 N6-acetyllysine; alternate.
Modified residue: 52 52 N6-succinyllysine; alternate.
Modified residue: 81 81 N6-succinyllysine.
Modified residue: 364 364 N6-acetyllysine; alternate.
Modified residue: 364 364 N6-succinyllysine; alternate.
Modified residue: 383 383 N6-acetyllysine; alternate.
Modified residue: 383 383 N6-succinyllysine; alternate.
Modified residue: 399 399 N6-acetyllysine; alternate.
Modified residue: 399 399 N6-succinyllysine; alternate.
Modified residue: 414 414 N6-acetyllysine; alternate.
Modified residue: 414 414 N6-succinyllysine; alternate.
Modified residue: 426 426 N6-acetyllysine; alternate.
Modified residue: 426 426 N6-succinyllysine; alternate.
Modified residue: 429 429 N6-acetyllysine.

Protein Length

517 AA.

Protein Sequence
(Canonical)

MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT  60
TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNLLAD LVERDRVYLA  120
SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPVGVCG  180
QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG  240
YGPTAGAAIA QHVDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM  300
EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP  360
QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP  420
VQPLFKFKKI EEVVERANNT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT  480
PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS                           517

FASTA
(Canonical)

>LipidDB-9606-00293|P30837
MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPT
TGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNLLADLVERDRVYLA
SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCG
QIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITG
YGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADM
EHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGP
QVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGP
VQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHT
PFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQKNS

Gene Ontology

GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA
GO:0005739; C:mitochondrion; IDA:HPA
GO:0005634; C:nucleus; IDA:HPA
GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:UniProtKB-EC
GO:0005975; P:carbohydrate metabolic process; NAS:ProtInc
GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway

Interpro

InterPro; IPR016161; Ald_DH/histidinol_DH
InterPro; IPR016163; Ald_DH_C
InterPro; IPR016160; Ald_DH_CS_CYS
InterPro; IPR029510; Ald_DH_CS_GLU
InterPro; IPR016162; Ald_DH_N
InterPro; IPR015590; Aldehyde_DH_dom

Pfam

Pfam; PF00171; Aldedh;

SMART

PROSITE

PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS;
PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU;

PRINTS