LipidDB ID

LipidDB-9606-00283

Entry Name

UniProt Accession

P62834; P10113;

Theoretical PI

6.39

Molecular Weight

20987.18

Genbank Protein ID

CAA31051.1; AAA36150.1; AAM12626.1; CAB55685.2; AAH14086.1;

Genbank Nucleotide ID

X12533; M22995; AF493912; AL049557; BC014086;

Protein Name

Ras-related protein Rap-1A

Protein Synonyms/Alias

C21KG; G-22K; GTP-binding protein smg p21A; Ras-related protein Krev-1;

Gene Name

RAP1A

Gene Synonyms/Alias

KREV1;

Created Date

16-AUG-2004

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Buss JE, Quilliam LA, Kato K, Casey PJ, Solski PA, Wong G, Clark R, McCormick F, Bokoch GM, Der CJ. The COOH-terminal domain of the Rap1A (Krev-1) protein isisoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. MolCell Biol. 1991 Mar;11(3):1523-30.[PMID:1899909]

Functional Description

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Motif: 32 40 Effector region.
Modified residue: 181 181 Cysteine methyl ester.

Protein Length

184 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030054; C:cell junction; ISS:UniProtKB
GO:0005737; C:cytoplasm; IDA:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0005769; C:early endosome; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:Ensembl
GO:0005770; C:late endosome; ISS:UniProtKB
GO:0043005; C:neuron projection; IEA:Ensembl
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; TAS:ProtInc
GO:0032403; F:protein complex binding; IDA:UniProtKB
GO:0008565; F:protein transporter activity; IDA:UniProtKB
GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB
GO:0000186; P:activation of MAPKK activity; TAS:Reactome
GO:0007596; P:blood coagulation; TAS:Reactome
GO:0071320; P:cellular response to cAMP; IDA:UniProtKB
GO:1990090; P:cellular response to nerve growth factor stimulus; ISS:UniProtKB
GO:0006112; P:energy reserve metabolic process; TAS:Reactome
GO:0061028; P:establishment of endothelial barrier; IMP:UniProtKB
GO:2000301; P:negative regulation of synaptic vesicle exocytosis; IEA:Ensembl
GO:0038180; P:nerve growth factor signaling pathway; ISS:UniProtKB
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome
GO:0030168; P:platelet activation; TAS:Reactome
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB
GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB
GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB
GO:0032854; P:positive regulation of Rap GTPase activity; ISS:UniProtKB
GO:2001214; P:positive regulation of vasculogenesis; ISS:UniProtKB
GO:0015031; P:protein transport; IDA:UniProtKB
GO:0032486; P:Rap protein signal transduction; IMP:UniProtKB
GO:1901888; P:regulation of cell junction assembly; IMP:UniProtKB
GO:0050796; P:regulation of insulin secretion; TAS:Reactome
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0044281; P:small molecule metabolic process; TAS:Reactome

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;