LipidDB ID

LipidDB-9606-00244

Entry Name

UniProt Accession

Q15286; B2R6E0; B4E390;

Theoretical PI

8.53

Molecular Weight

23025.22

Genbank Protein ID

CAA56177.1; AAM21108.1; AAV38827.1; CAG38725.1; CAG46484.1; BAG65402.1; BAG35437.1; AAC83182.1; EAW98163.1; EAW98164.1; AAH15931.1;

Genbank Nucleotide ID

X79781; AF498960; BT020024; CR536486; CR541683; AK304620; AK312538; AC004812; CH471054; CH471054; BC015931;

Protein Name

Ras-related protein Rab-35

Protein Synonyms/Alias

GTP-binding protein RAY; Ras-related protein Rab-1C;

Gene Name

RAB35

Gene Synonyms/Alias

RAB1C; RAY;

Created Date

15-JUL-1998

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Gavriljuk K, Itzen A, Goody RS, Gerwert K, Kötting C. Membrane extraction ofRab proteins by GDP dissociation inhibitor characterized using attenuated totalreflection infrared spectroscopy. Proc Natl Acad Sci U S A. 2013 Aug13;110(33):13380-5. doi: 10.1073/pnas.1307655110. Epub 2013 Jul 29.[PMID:23898197]

Functional Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth.

Sequence Annotation

Nucleotide-binding: 15 22 GTP.
Nucleotide-binding: 63 67 GTP.
Nucleotide-binding: 120 123 GTP.
Motif: 37 45 Effector region.
Modified residue: 75 75 O-(2-cholinephosphoryl)serine; byLegionella AnkX.
Modified residue: 77 77 O-AMP-tyrosine; by Legionella DrrA.

Protein Length

201 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0031253; C:cell projection membrane; IDA:UniProtKB
GO:0045334; C:clathrin-coated endocytic vesicle; IDA:UniProtKB
GO:0005905; C:coated pit; IDA:UniProtKB
GO:0010008; C:endosome membrane; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0045171; C:intercellular bridge; IDA:UniProtKB
GO:0005739; C:mitochondrion; IEA:Ensembl
GO:0005886; C:plasma membrane; IDA:UniProtKB
GO:0019003; F:GDP binding; IDA:UniProtKB
GO:0005525; F:GTP binding; IDA:UniProtKB
GO:0003924; F:GTPase activity; IDA:UniProtKB
GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB
GO:0019882; P:antigen processing and presentation; IMP:UniProt
GO:1990090; P:cellular response to nerve growth factor stimulus; ISS:UniProtKB
GO:0000910; P:cytokinesis; IMP:UniProtKB
GO:0016197; P:endosomal transport; IMP:UniProtKB
GO:0006184; P:GTP catabolic process; IDA:UniProtKB
GO:0031175; P:neuron projection development; ISS:UniProtKB
GO:0048227; P:plasma membrane to endosome transport; IMP:UniProtKB
GO:0008104; P:protein localization; IMP:UniProtKB
GO:0036010; P:protein localization to endosome; IMP:UniProtKB
GO:0015031; P:protein transport; IEA:UniProtKB-KW
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00175; RAB;

PROSITE

PROSITE; PS51419; RAB;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;