Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00238
Entry Name
UniProt Accession
Theoretical PI
9.01
Molecular Weight
42280.19
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Protein Synonyms/Alias
2.7.8.27; Sphingomyelin synthase 2;
Gene Name
SGMS2
Gene Synonyms/Alias
SMS2;
Created Date
01-MAR-2004
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
331
Canonical
NVQGSIPCCFSWPLS
[1]
S-Palmitoylation
332
Canonical
VQGSIPCCFSWPLSW
[1]
S-Palmitoylation
343
Canonical
PLSWPPGCFKSSCKK
[1]
S-Palmitoylation
348
Canonical
PGCFKSSCKKYSRVQ
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Tani M, Kuge O. Sphingomyelin synthase 2 is palmitoylated at the COOH-terminaltail, which is involved in its localization in plasma membranes. Biochem Biophys Res Commun. 2009 Apr 10;381(3):328-32. doi: 10.1016/j.bbrc.2009.02.063. Epub 2009Feb 20.[PMID:19233134]
Functional Description
Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity.
Sequence Annotation
Transmembrane: 80 100 Helical.
Transmembrane: 128 148 Helical.
Transmembrane: 159 179 Helical.
Transmembrane: 206 226 Helical.
Transmembrane: 248 268 Helical.
Transmembrane: 275 295 Helical.
Topological domain: 296 365 Cytoplasmic.
Active site: 229 229
Active site: 272 272
Active site: 276 276
Protein Length
365 AA.
Protein Sequence
(Canonical)
MDIIETAKLE EHLENQPSDP TNTYARPAEP VEEENKNGNG KPKSLSSGLR KGTKKYPDYI  60
QIAMPTESRN KFPLEWWKTG IAFIYAVFNL VLTTVMITVV HERVPPKELS PPLPDKFFDY  120
IDRVKWAFSV SEINGIILVG LWITQWLFLR YKSIVGRRFC FIIGTLYLYR CITMYVTTLP  180
VPGMHFQCAP KLNGDSQAKV QRILRLISGG GLSITGSHIL CGDFLFSGHT VTLTLTYLFI  240
KEYSPRHFWW YHLICWLLSA AGIICILVAH EHYTIDVIIA YYITTRLFWW YHSMANEKNL  300
KVSSQTNFLS RAWWFPIFYF FEKNVQGSIP CCFSWPLSWP PGCFKSSCKK YSRVQKIGED  360
NEKST                                                              365
FASTA
(Canonical)
>LipidDB-9606-00238|Q8NHU3
MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYI
QIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDY
IDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLP
VPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFI
KEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNL
KVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGED
NEKST
Gene Ontology
GO:0005794; C:Golgi apparatus; IDA:MGI
GO:0045203; C:integral component of cell outer membrane; IEA:Ensembl
GO:0030173; C:integral component of Golgi membrane; IDA:UniProtKB
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0047493; F:ceramide cholinephosphotransferase activity; IDA:UniProtKB
GO:0016301; F:kinase activity; IEA:UniProtKB-KW
GO:0033188; F:sphingomyelin synthase activity; IEA:UniProtKB-EC
GO:0044281; P:small molecule metabolic process; TAS:Reactome
GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome
GO:0006665; P:sphingolipid metabolic process; TAS:Reactome
GO:0006686; P:sphingomyelin biosynthetic process; IDA:UniProtKB
Interpro
InterPro; IPR025749; Sphingomyelin_synth-like_dom
Pfam
Pfam; PF14360; PAP2_C;
SMART
PROSITE
PRINTS