Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00228
Entry Name
UniProt Accession
Theoretical PI
5.08
Molecular Weight
56465.57
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Potassium voltage-gated channel subfamily A member 1
Protein Synonyms/Alias
Voltage-gated K(+) channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1;
Gene Name
KCNA1
Gene Synonyms/Alias
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
243
Canonical
LVVRFFACPSKTDFF
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Gubitosi-Klug RA, Mancuso DJ, Gross RW. The human Kv1.1 channel ispalmitoylated, modulating voltage sensing: Identification of a palmitoylationconsensus sequence. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5964-8. Epub2005 Apr 18.[PMID:15837928]
Functional Description
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Sequence Annotation
Transmembrane: 168 186 Helical; Name=Segment S1.
Transmembrane: 221 242 Helical; Name=Segment S2.
Transmembrane: 254 274 Helical; Name=Segment S3.
Transmembrane: 290 309 Helical; Voltage-sensor; Name=Segment S4.
Transmembrane: 326 345 Helical; Name=Segment S5.
Transmembrane: 387 408 Helical; Name=Segment S6.
Motif: 372 377 Selectivity filter.
Motif: 493 495 PDZ-binding.
Modified residue: 322 322 Phosphoserine; by PKA.
Modified residue: 445 445 Phosphoserine; by PKA.
Protein Length
495 AA.
Protein Sequence
(Canonical)
MTVMSGENVD EASAAPGHPQ DGSYPRQADH DDHECCERVV INISGLRFET QLKTLAQFPN  60
TLLGNPKKRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG RLRRPVNVPL DMFSEEIKFY  120
ELGEEAMEKF REDEGFIKEE ERPLPEKEYQ RQVWLLFEYP ESSGPARVIA IVSVMVILIS  180
IVIFCLETLP ELKDDKDFTG TVHRIDNTTV IYNSNIFTDP FFIVETLCII WFSFELVVRF  240
FACPSKTDFF KNIMNFIDIV AIIPYFITLG TEIAEQEGNQ KGEQATSLAI LRVIRLVRVF  300
RIFKLSRHSK GLQILGQTLK ASMRELGLLI FFLFIGVILF SSAVYFAEAE EAESHFSSIP  360
DAFWWAVVSM TTVGYGDMYP VTIGGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETE  420
GEEQAQLLHV SSPNLASDSD LSRRSSSTMS KSEYMEIEED MNNSIAHYRQ VNIRTANCTT  480
ANQNCVNKSK LLTDV                                                   495
FASTA
(Canonical)
>LipidDB-9606-00228|Q09470
MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPN
TLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFY
ELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILIS
IVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRF
FACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVF
RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIP
DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETE
GEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTT
ANQNCVNKSKLLTDV
Gene Ontology
GO:0016324; C:apical plasma membrane; IEA:Ensembl
GO:0030425; C:dendrite; IEA:Ensembl
GO:0044224; C:juxtaparanode region of axon; ISS:BHF-UCL
GO:0043025; C:neuronal cell body; IEA:Ensembl
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0008076; C:voltage-gated potassium channel complex; TAS:ProtInc
GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome
GO:0005267; F:potassium channel activity; TAS:ProtInc
GO:0015079; F:potassium ion transmembrane transporter activity; TAS:ProtInc
GO:0006813; P:potassium ion transport; TAS:ProtInc
GO:0051260; P:protein homooligomerization; IEA:InterPro
GO:0007268; P:synaptic transmission; TAS:Reactome
Interpro
InterPro; IPR000210; BTB/POZ-like
InterPro; IPR011333; BTB/POZ_fold
InterPro; IPR027359; Channel_four-helix_dom
InterPro; IPR005821; Ion_trans_dom
InterPro; IPR003091; K_chnl
InterPro; IPR003968; K_chnl_volt-dep_Kv
InterPro; IPR003972; K_chnl_volt-dep_Kv1
InterPro; IPR004048; K_chnl_volt-dep_Kv1.1
InterPro; IPR003131; T1-type_BTB
InterPro; IPR028325; VG_K_chnl
Pfam
Pfam; PF02214; BTB_2;
Pfam; PF00520; Ion_trans;
SMART
SMART; SM00225; BTB;
PROSITE
PRINTS
PRINTS; PR00169; KCHANNEL;
PRINTS; PR01508; KV11CHANNEL;
PRINTS; PR01491; KVCHANNEL;
PRINTS; PR01496; SHAKERCHANEL;