| Tag |
Content |
LipidDB ID |
LipidDB-9606-00223 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.18 |
Molecular Weight |
136694.62 |
Genbank Protein ID |
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Genbank Nucleotide ID |
|
Protein Name |
G-protein coupled receptor 126 |
Protein Synonyms/Alias |
Developmentally regulated G-protein-coupled receptor; Vascular inducible G protein-coupled receptor; |
Gene Name |
GPR126 |
Gene Synonyms/Alias |
DREG; VIGR; |
Created Date |
19-JUL-2004 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
11 | Canonical | RSDRMWSCHWKWKPS | [1] | S-Palmitoylation | 930 | Canonical | SFNVDGLCIAVAVLL | [1] | S-Palmitoylation | 975 | Canonical | RRYILKFCIIGWGLP | [1] | S-Palmitoylation | 1048 | Canonical | IVVMVQICGRNGKRS | [1] | S-Palmitoylation | 1130 | Canonical | KQWRQHLCCGRFRLA | [1] | S-Palmitoylation | 1131 | Canonical | QWRQHLCCGRFRLAD | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity). |
Sequence Annotation |
Topological domain: 38 862 Extracellular.
Transmembrane: 863 883 Helical; Name=1.
Topological domain: 884 903 Cytoplasmic.
Transmembrane: 904 924 Helical; Name=2.
Topological domain: 925 929 Extracellular.
Transmembrane: 930 950 Helical; Name=3.
Topological domain: 951 970 Cytoplasmic.
Transmembrane: 971 991 Helical; Name=4.
Topological domain: 992 1024 Extracellular.
Transmembrane: 1025 1045 Helical; Name=5.
Topological domain: 1046 1069 Cytoplasmic.
Transmembrane: 1070 1090 Helical; Name=6.
Topological domain: 1091 1092 Extracellular.
Transmembrane: 1093 1113 Helical; Name=7.
Topological domain: 1114 1221 Cytoplasmic.
Domain: 41 149 CUB.
Domain: 150 355 Pentaxin.
Domain: 800 852 GPS.
Functional site: 467 468 Cleavage; by furin like-convertase.
Functional site: 840 841 Cleavage.
Modified residue: 1165 1165 Phosphoserine.
|
Protein Length |
1221 AA. |
Protein Sequence
(Canonical) |
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG TFTSPCYPND 60
YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS LDNGESQTKF CGATAKGLSF 120
NSSANEMHVS FSSDFSIQKK GFNASYIRVA VSLRNQKVIL PQTSDAYQVS VAKSISIPEL 180
SAFTLCFEAT KVGHEDSDWT AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK 240
EKEDIFAESF EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 300
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA ESNLSCGSYL 360
IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN RIDKQRNDGI IYRISVVIQN 420
ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV VNISFHLSAG EDKIKVKRSL EDEPRLVLWA 480
LLVYNATNNT NLEGKIIQQK LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ 540
PSEYVLPCPD KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN 600
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS SEALKTIDEL 660
AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL PSNNESYFQM DFESGQVDPL 720
ASVILPPNLL ENLSPEDSVL VRRAQFTFFN KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ 780
NLKDPVQIKI KHTRTQEVHH PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF 840
THFGVLMDLP RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI 900
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL EAIHMYIALV 960
KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG KESYGKEKGD EFCWIQDPVI 1020
FYVTCAGYFG VMFFLNIAMF IVVMVQICGR NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT 1080
WGFAFFAWGP LNIPFMYLFS IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS 1140
DWSKTATNII KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF 1200
NKSGSLRQCF HGQVLVKTGP C 1221
|
FASTA
(Canonical) |
>LipidDB-9606-00223|Q86SQ4
MMFRSDRMWSCHWKWKPSPLLFLFALYIMCVPHSVWGCANCRVVLSNPSGTFTSPCYPND
YPNSQACMWTLRAPTGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCGATAKGLSF
NSSANEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVILPQTSDAYQVSVAKSISIPEL
SAFTLCFEATKVGHEDSDWTAFSYSNASFTQLLSFGKAKSGYFLSISDSKCLLNNALPVK
EKEDIFAESFEQLCLVWNNSLGSIGVNFKRNYETVPCDSTISKVIPGNGKLLLGSNQNEI
VSLKGDIYNFRLWNFTMNAKILSNLSCNVKGNVVDWQNDFWNIPNLALKAESNLSCGSYL
IPLPAAELASCADLGTLCQATVNSPSTTPPTVTTNMPVTNRIDKQRNDGIIYRISVVIQN
ILRHPEVKVQSKVAEWLNSTFQNWNYTVYVVNISFHLSAGEDKIKVKRSLEDEPRLVLWA
LLVYNATNNTNLEGKIIQQKLLKNNESLDEGLRLHTVNVRQLGHCLAMEEPKGYYWPSIQ
PSEYVLPCPDKPGFSASRICFYNATNPLVTYWGPVDISNCLKEANEVANQILNLTADGQN
LTSANITNIVEQVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSSEALKTIDEL
AFKIDLNSTSHVNITTRNLALSVSSLLPGTNAISNFSIGLPSNNESYFQMDFESGQVDPL
ASVILPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQ
NLKDPVQIKIKHTRTQEVHHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHF
THFGVLMDLPRSASQLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSKI
LMNLSTALLFLNLLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALV
KVFNTYIRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQDPVI
FYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMT
WGFAFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNS
DWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDNVSYEHSF
NKSGSLRQCFHGQVLVKTGPC
|
Gene Ontology |
GO:0016021; C:integral component of membrane; TAS:GDB GO:0005886; C:plasma membrane; IEA:UniProtKB-KW GO:0004930; F:G-protein coupled receptor activity; TAS:GDB GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:GDB GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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