| Tag |
Content |
LipidDB ID |
LipidDB-9606-00222 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
9.39 |
Molecular Weight |
87082.15 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Plakophilin-3 |
Protein Synonyms/Alias |
|
Gene Name |
PKP3 |
Gene Synonyms/Alias |
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Created Date |
23-JAN-2002 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
569 | Canonical | PPGEVVGCFTPQSRR | [1] | S-Palmitoylation |
|
Organism |
Homo sapiens (Human) |
NCBI Taxa ID |
9606 |
Reference |
[1] Roberts BJ, Johnson KE, McGuinn KP, Saowapa J, Svoboda RA, Mahoney MG, JohnsonKR, Wahl JK 3rd. Palmitoylation of plakophilin is required for desmosomeassembly. J Cell Sci. 2014 Sep 1;127(Pt 17):3782-93. doi: 10.1242/jcs.149849.Epub 2014 Jul 7.[ PMID:25002405]
|
Functional Description |
May play a role in junctional plaques. |
Sequence Annotation |
Modified residue: 180 180 Phosphoserine.
Modified residue: 238 238 Phosphoserine.
Modified residue: 240 240 Phosphoserine.
Modified residue: 313 313 Phosphoserine.
Modified residue: 314 314 Phosphoserine.
|
Protein Length |
797 AA. |
Protein Sequence
(Canonical) |
MQDGNFLLSA LQPEAGVCSL ALPSDLQLDR RGAEGPEAER LRAARVQEQV RARLLQLGQQ 60
PRHNGAAEPE PEAETARGTS RGQYHTLQAG FSSRSQGLSG DKTSGFRPIA KPAYSPASWS 120
SRSAVDLSCS RRLSSAHNGG SAFGAAGYGG AQPTPPMPTR PVSFHERGGV GSRADYDTLS 180
LRSLRLGPGG LDDRYSLVSE QLEPAATSTY RAFAYERQAS SSSSRAGGLD WPEATEVSPS 240
RTIRAPAVRT LQRFQSSHRS RGVGGAVPGA VLEPVARAPS VRSLSLSLAD SGHLPDVHGF 300
NSYGSHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHKCYSD AAAKKQARSL 360
QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNADNKLALV EENGIFELLR TLREQDDELR 420
KNVTGILWNL SSSDHLKDRL ARDTLEQLTD LVLSPLSGAG GPPLIQQNAS EAEIFYNATG 480
FLRNLSSASQ ATRQKMRECH GLVDALVTSI NHALDAGKCE DKSVENAVCV LRNLSYRLYD 540
EMPPSALQRL EGRGRRDLAG APPGEVVGCF TPQSRRLREL PLAADALTFA EVSKDPKGLE 600
WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA LEQERILNPL 660
LDRVRTADHH QLRSLTGLIR NLSRNARNKD EMSTKVVSHL IEKLPGSVGE KSPPAEVLVN 720
IIAVLNNLVV ASPIAARDLL YFDGLRKLIF IKKKRDSPDS EKSSRAASSL LANLWQYNKL 780
HRDFRAKGYR KEDFLGP 797
|
FASTA
(Canonical) |
>LipidDB-9606-00222|Q9Y446
MQDGNFLLSALQPEAGVCSLALPSDLQLDRRGAEGPEAERLRAARVQEQVRARLLQLGQQ
PRHNGAAEPEPEAETARGTSRGQYHTLQAGFSSRSQGLSGDKTSGFRPIAKPAYSPASWS
SRSAVDLSCSRRLSSAHNGGSAFGAAGYGGAQPTPPMPTRPVSFHERGGVGSRADYDTLS
LRSLRLGPGGLDDRYSLVSEQLEPAATSTYRAFAYERQASSSSSRAGGLDWPEATEVSPS
RTIRAPAVRTLQRFQSSHRSRGVGGAVPGAVLEPVARAPSVRSLSLSLADSGHLPDVHGF
NSYGSHRTLQRLSSGFDDIDLPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSL
QAVPRLVKLFNHANQEVQRHATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELR
KNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATG
FLRNLSSASQATRQKMRECHGLVDALVTSINHALDAGKCEDKSVENAVCVLRNLSYRLYD
EMPPSALQRLEGRGRRDLAGAPPGEVVGCFTPQSRRLRELPLAADALTFAEVSKDPKGLE
WLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLALEQERILNPL
LDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGEKSPPAEVLVN
IIAVLNNLVVASPIAARDLLYFDGLRKLIFIKKKRDSPDSEKSSRAASSLLANLWQYNKL
HRDFRAKGYRKEDFLGP
|
Gene Ontology |
GO:0005911; C:cell-cell junction; TAS:ProtInc GO:0030057; C:desmosome; IEA:Ensembl GO:0005634; C:nucleus; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; IDA:UniProt GO:0050839; F:cell adhesion molecule binding; IPI:UniProt GO:0002159; P:desmosome assembly; IMP:UniProt GO:0090002; P:establishment of protein localization to plasma membrane; IMP:UniProt GO:0016337; P:single organismal cell-cell adhesion; IEA:InterPro |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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