Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00204
Entry Name
UniProt Accession
Theoretical PI
9.81
Molecular Weight
17342.35
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Protein FAM162A
Protein Synonyms/Alias
E2-induced gene 5 protein; Growth and transformation-dependent protein; HGTD-P;
Gene Name
FAM162A
Gene Synonyms/Alias
C3orf28; E2IG5; DC16; FWP001;
Created Date
31-OCT-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
18
Canonical
AGSCFRLCERDVSSS
[1]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Predicted from GPS-Lipid
Functional Description
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
Sequence Annotation
Transmembrane: 103 120 Helical.
Region: 76 102 Required for proapoptotic activity.
Protein Length
154 AA.
Protein Sequence
(Canonical)
MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGA PSRTYNRVPL  60
HKPTDWQKKI LIWSGRFKKE DEIPETVSLE MLDAAKNKMR VKISYLMIAL TVVGCIFMVI  120
EGKKAAQRHE TLTSLNLEKK ARLKEEAAMK AKTE                              154
FASTA
(Canonical)
>LipidDB-9606-00204|Q96A26
MGSLSGLRLAAGSCFRLCERDVSSSLRLTRSSDLKRINGFCTKPQESPGAPSRTYNRVPL
HKPTDWQKKILIWSGRFKKEDEIPETVSLEMLDAAKNKMRVKISYLMIALTVVGCIFMVI
EGKKAAQRHETLTSLNLEKKARLKEEAAMKAKTE
Gene Ontology
GO:0005737; C:cytoplasm; IDA:HPA
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005739; C:mitochondrion; IDA:HPA
GO:0005634; C:nucleus; IDA:HPA
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB
GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB
GO:0051402; P:neuron apoptotic process; IEA:Ensembl
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IDA:UniProtKB
GO:0006927; P:transformed cell apoptotic process; IDA:UniProtKB
Interpro
InterPro; IPR009432; DUF1075
Pfam
Pfam; PF06388; DUF1075;
SMART
PROSITE
PRINTS