LipidDB ID

LipidDB-9606-00200

Entry Name

UniProt Accession

Q9BTU6; D3DR59; Q9NSG8;

Theoretical PI

8.51

Molecular Weight

54022.37

Genbank Protein ID

CAC38065.1; AAP35994.1; CAI15460.1; EAW49906.1; EAW49907.1; AAH03167.1; CAB89254.1;

Genbank Nucleotide ID

AJ303098; BT007330; AL355315; CH471066; CH471066; BC003167; AL353952;

Protein Name

Phosphatidylinositol 4-kinase type 2-alpha

Protein Synonyms/Alias

2.7.1.67; Phosphatidylinositol 4-kinase type II-alpha;

Gene Name

PI4K2A

Gene Synonyms/Alias

Created Date

01-MAY-2007

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Reference

[1] Predicted from GPS-Lipid

Functional Description

Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells (By similarity). This lipid kinase is the major phosphatidylinositol 4-phosphate (PI4P) producer in the Golgi apparatus, it generates more than 50% of this molecule which is essential for the identity of the organelle, protein sorting and membrane trafficking.

Sequence Annotation

Domain: 133 438 PI3K/PI4K.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 5 5 Phosphoserine.
Modified residue: 9 9 Phosphoserine.
Modified residue: 47 47 Phosphoserine.
Modified residue: 51 51 Phosphoserine.
Modified residue: 462 462 Phosphoserine.
Modified residue: 464 464 Phosphoserine.

Protein Length

479 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB
GO:0005829; C:cytosol; TAS:Reactome
GO:0030425; C:dendrite; ISS:UniProtKB
GO:0031901; C:early endosome membrane; IEA:Ensembl
GO:0005768; C:endosome; ISS:UniProtKB
GO:0070382; C:exocytic vesicle; IEA:Ensembl
GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW
GO:0035838; C:growing cell tip; ISS:UniProtKB
GO:0044231; C:host cell presynaptic membrane; ISS:UniProtKB
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB
GO:0005765; C:lysosomal membrane; IDA:UniProtKB
GO:0016020; C:membrane; IDA:UniProtKB
GO:0045121; C:membrane raft; IDA:UniProtKB
GO:0005739; C:mitochondrion; ISS:UniProtKB
GO:0043005; C:neuron projection; ISS:UniProtKB
GO:0043025; C:neuronal cell body; ISS:UniProtKB
GO:0043204; C:perikaryon; IEA:Ensembl
GO:0042734; C:presynaptic membrane; ISS:UniProtKB
GO:0043234; C:protein complex; IEA:Ensembl
GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl
GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IDA:UniProtKB
GO:0035651; F:AP-3 adaptor complex binding; IDA:UniProtKB
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0000287; F:magnesium ion binding; NAS:UniProtKB
GO:0002561; P:basophil degranulation; IEA:Ensembl
GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB
GO:0046854; P:phosphatidylinositol phosphorylation; IDA:GOC
GO:0006644; P:phospholipid metabolic process; TAS:Reactome
GO:0044281; P:small molecule metabolic process; TAS:Reactome

Interpro

InterPro; IPR000403; PI3/4_kinase_cat_dom

Pfam

Pfam; PF00454; PI3_PI4_kinase;

SMART

PROSITE

PRINTS