Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-9606-00197
Entry Name
UniProt Accession
Theoretical PI
8.29
Molecular Weight
37732.2
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Tumor necrosis factor receptor superfamily member 6
Protein Synonyms/Alias
Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD95;
Gene Name
FAS
Gene Synonyms/Alias
APT1; FAS1; TNFRSF6;
Created Date
01-MAY-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
199
Canonical
RKEVQKTCRKHRKEN
[1][2]
S-Palmitoylation
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Reference
[1] Feig C, Tchikov V, Schütze S, Peter ME. Palmitoylation of CD95 facilitatesformation of SDS-stable receptor aggregates that initiate apoptosis signaling.EMBO J. 2007 Jan 10;26(1):221-31. Epub 2006 Dec 7.[PMID:17159907]
[2] Chakrabandhu K, Hérincs Z, Huault S, Dost B, Peng L, Conchonaud F, Marguet D, He HT, Hueber AO. Palmitoylation is required for efficient Fas cell deathsignaling. EMBO J. 2007 Jan 10;26(1):209-20. Epub 2006 Dec 7.[PMID:17159908]
Functional Description
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Sequence Annotation
Topological domain: 26 173 Extracellular.
Transmembrane: 174 190 Helical.
Topological domain: 191 335 Cytoplasmic.
Domain: 230 314 Death.
Region: 212 317 Interaction with HIPK3.
Modified residue: 209 209 Phosphoserine.
Protein Length
335 AA.
Protein Sequence
(Canonical)
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE GLHHDGQFCH  60
KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK CRRCRLCDEG HGLEVEINCT  120
RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE HGIIKECTLT SNTKCKEEGS RSNLGWLCLL  180
LLPIPLIVWV KRKEVQKTCR KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM  240
TLSQVKGFVR KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK  300
ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV                             335
FASTA
(Canonical)
>LipidDB-9606-00197|P25445
MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCH
KPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCT
RTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLL
LLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVM
TLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKK
ANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
Gene Ontology
GO:0031265; C:CD95 death-inducing signaling complex; IDA:UniProtKB
GO:0009986; C:cell surface; IDA:UniProtKB
GO:0005737; C:cytoplasm; IDA:HPA
GO:0005829; C:cytosol; NAS:UniProtKB
GO:0031264; C:death-inducing signaling complex; IDA:UniProtKB
GO:0009897; C:external side of plasma membrane; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IDA:UniProt
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0045121; C:membrane raft; IDA:UniProtKB
GO:0005634; C:nucleus; IDA:HPA
GO:0005886; C:plasma membrane; IMP:UniProtKB
GO:0042802; F:identical protein binding; IPI:IntAct
GO:0019900; F:kinase binding; IPI:BHF-UCL
GO:0004872; F:receptor activity; NAS:UniProtKB
GO:0004871; F:signal transducer activity; TAS:ProtInc
GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome
GO:0006924; P:activation-induced cell death of T cells; IEA:Ensembl
GO:0006915; P:apoptotic process; IDA:MGI
GO:0097190; P:apoptotic signaling pathway; TAS:Reactome
GO:0019724; P:B cell mediated immunity; IEA:Ensembl
GO:0071455; P:cellular response to hyperoxia; IMP:UniProtKB
GO:0071285; P:cellular response to lithium ion; IEA:Ensembl
GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB
GO:0007623; P:circadian rhythm; IEA:Ensembl
GO:0097191; P:extrinsic apoptotic signaling pathway; IMP:UniProtKB
GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl
GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl
GO:0002377; P:immunoglobulin production; IEA:Ensembl
GO:0006925; P:inflammatory cell apoptotic process; IEA:Ensembl
GO:0097049; P:motor neuron apoptotic process; IEA:Ensembl
GO:0097527; P:necroptotic signaling pathway; IMP:BHF-UCL
GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc
GO:0050869; P:negative regulation of B cell activation; IEA:Ensembl
GO:0045060; P:negative thymic T cell selection; IEA:Ensembl
GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB
GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl
GO:0032464; P:positive regulation of protein homooligomerization; IEA:Ensembl
GO:0006461; P:protein complex assembly; TAS:ProtInc
GO:0051260; P:protein homooligomerization; IEA:Ensembl
GO:0042981; P:regulation of apoptotic process; NAS:UniProtKB
GO:2001239; P:regulation of extrinsic apoptotic signaling pathway in absence of ligand; TAS:Reactome
GO:0045619; P:regulation of lymphocyte differentiation; IEA:Ensembl
GO:0045637; P:regulation of myeloid cell differentiation; IEA:Ensembl
GO:0003014; P:renal system process; IEA:Ensembl
GO:0051384; P:response to glucocorticoid; IEA:Ensembl
GO:0009636; P:response to toxic substance; IEA:Ensembl
GO:0007165; P:signal transduction; TAS:ProtInc
GO:0048536; P:spleen development; IEA:Ensembl
GO:0006927; P:transformed cell apoptotic process; IEA:Ensembl
Interpro
InterPro; IPR011029; DEATH-like_dom
InterPro; IPR000488; Death_domain
InterPro; IPR008063; Fas_rcpt
InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg
Pfam
Pfam; PF00531; Death;
Pfam; PF00020; TNFR_c6;
SMART
SMART; SM00005; DEATH;
SMART; SM00208; TNFR;
PROSITE
PROSITE; PS50017; DEATH_DOMAIN;
PROSITE; PS00652; TNFR_NGFR_1;
PROSITE; PS50050; TNFR_NGFR_2;
PRINTS
PRINTS; PR01680; TNFACTORR6;